This book summarizes the research that resulted in aspartame's approval as a food additive as well as related topics regarding its function as a potential sweetening agent. It complies specific issues relating to human consumption of aspartame.

part |25 pages

History and Background

chapter 1|7 pages

Discovery of Aspartame

ByRobert H. Mazur

chapter 2|15 pages

Sweeteners: An Overall Perspective

ByGeorge E. Inglett

part |173 pages


chapter 3|18 pages

Absorption of Peptides, Amino Acids, and Their Methylated Derivatives

ByDavid M. Matthews

chapter 4|30 pages

Aspartate and Glutamate Metabolism

ByLewis D. Stegink

chapter 5|33 pages

Phenylalanine Metabolism

ByAlfred E. Harper

chapter 6|30 pages

Methanol Metabolism and Toxicity

ByThomas R. Tephly, Kenneth E. McMartin

chapter 7|19 pages

Aspartame Metabolism in Animals

ByJames A. Oppermann

chapter 8|39 pages

Tissue Distribution of Orally Administered Isotopically Labeled Aspartame in the Rat

ByYoshimasa Matsuzawa, Yuichi O'Hara


Sensory and Dietary Aspects

chapter 9|5 pages

Projected Aspartame Intake: Daily Ingestion of Aspartic Acid, Phenylalanine, and Methanol

ByRoberta Roak-Foltz, Gilbert A. Leveille

chapter 10|40 pages

Comparison of Taste Properties of Aspartame with Other Sweeteners

BySusan S. Schiffman

chapter 11|16 pages

Aspartame: Implications for the Food Scientist

ByBarry E. Homler

chapter 12|10 pages

Role of Sugar and Other Sweeteners in Dental Caries

ByWilliam H. Bowen

chapter 13|14 pages

Efficacy of Low-Calorie Sweeteners in Reducing Food Intake: Studies with Aspartame

ByKatherine P. Porikos, Theodore B. Van

part |206 pages

Preclinical Studies

chapter 14|18 pages

Preclinical Studies of Aspartame in Nonprimate Animals

BySamuel V. Molinary

chapter 15|13 pages

Chronic Feeding Studies with Aspartame and Its Diketopiperazine

ByHiroyuka Ishii

chapter 17|14 pages

Aspartate-Induced Neurotoxicity in Infant Mice

ByArnold E. Applebaum, Tahia T. Daabees, Lewis D. Stegink, Michael W. Finkelstein

chapter 18|16 pages

Neuropathology Studies Following Aspartame Ingestion by Infant Nonhuman Primates

ByW. Ann Reynolds, Linda Parsons, Lewis D. Stegink

chapter 19|26 pages

Behavioral Testing in Rodents Given Food Additives

ByRichard E. Butcher, Charles V. Vorhees

chapter 20|19 pages

Developmental Assessment of Infant Macaques Receiving Dietary Aspartame or Phenylalanine

ByW. Ann Reynolds, Anne F. Bauman, Lewis B. Stegink, L. J. Filer, Sakkubai Naidu

chapter 22|11 pages

Aspartame and Brain Tumors: Pathology Issues

ByAdalbert Koestner

chapter 23|21 pages

Aspartame and Brain Tumors: Statistical Issues

ByRichard G. Cornell, Robert A. Wolfe, Paul G. Sanders

chapter 24|12 pages

Possible Neurohormonal Effects of Aspartame Ingestion

ByFrank M. Sturtevant

part |161 pages

Studies of Aspartame Metabolism in Humans

chapter 25|14 pages

Chronic Ingestion of Aspartame in Humans

ByWillard J. Visek

chapter 26|45 pages

Aspartame Metabolism in Humans: Acute Dosing Studies

ByLewis D. Stegink

chapter 27|9 pages

Aspartame Ingestion During Pregnancy

ByRoy M. Pitkin

chapter 28|13 pages

Aspartame Ingestion During Lactation

ByGeorge L. Baker

chapter 29|13 pages

Aspartame Ingestion by Human Infants

ByL. J. Filer, George L. Baker, Lewis D. Stegink

chapter 30|14 pages

Aspartame Ingestion by Phenylketonuric Heterozygous and Homozygous Individuals

ByRichard Koch, Elizabeth J. Wenz

chapter 31|26 pages

Interactions of Aspartame and Glutamate Metabolism

ByLewis D. Stegink

chapter 32|7 pages

Aspartame Use by Persons with Diabetes

ByDavid L. Horwitz