ABSTRACT

This reference spotlights the immunologic aspects of applying interferon-gamma to the treatment of infectious diseases - revealing the current knowledge of the biology and potential utility of interferon-gamma.;Written by more than 30 leading investigators in the field, Anti-Infective Applications of Interferon-Gamma: presents information according to specific patient populations and pathogens; focuses on only the most promising of emerging therapeutic agents; furnishes a detailed update of the pleiotropic role of interferon-gamma in host defense; and studies clinical and preclinical experiences in a broad variety of disease indications.;Containing over 900 bibliographic citations for further research, this book should be useful for infectious disease specialists, pharmacologists, immunologists, surgeons, pediatricians, parasitologists, hematologists, virologists, microbiologists, pathologists, oncologists and tropical medicine specialists.

chapter 1|8 pages

The Interferons

A Clinical Overview
ByHoward S. Jaffe

part I|76 pages

Target Populations

chapter 2|18 pages

Interferon-Gamma Treatment of Chronic Granulomatous Disease

ByAllen E. Izu, Howard S. Jaffe, John T. Curnutte, R. Alan B. Ezekowitz

chapter 3|8 pages

Infection Associated with the Surgical Care of the Major Trauma Victim

ByHiram C. Polk, William G. Cheadle, Gerald Sonnenfeld, Michael J. Hershman

chapter 4|16 pages

Potential Role of Interferon-Gamma in Human Immunodeficiency Virus-Associated Disease

ByDavid Aboulafia, Ronald T. Mitsuyasu

chapter 5|14 pages

Interferon-Gamma in the Neonate

ByHarry R. Hill

chapter 6|18 pages

Atopie Dermatitis

ByMark Boguniewicz, Donald Leung

part II|208 pages

Target Infections

chapter 7|36 pages

The Role of Interferon-Gamma in Resistance Against Toxoplasma gondii

ByCarlos S. Subauste, Jack S. Remington

chapter 8|14 pages

Leishmaniasis and Interferon-Gamma

BySusan M. Kramer

chapter 9|22 pages

Interferon-Gamma in Trypanosoma cruzi Infections

BySteven G. Reed, Joao Santana Da Silva

chapter 10|10 pages

Interferon-Gamma and Immunity to Malaria Sporozoites

Implications for the Development of Synthetic Vaccines
ByLouis Schofield

chapter 11|20 pages

Interferon-Gamma for Human Papillomavirus Infection

ByPhilip Kirby, Lawrence Corey

chapter 12|12 pages

Herpes Simplex as a Target for Anti-Infective Applications of Interferon-Gamma

Preclinical In Vitro and In Vivo Observations
ByAnn M. Arvin

chapter 13|12 pages

The Role of Interferon in Cytomegalovirus Infection

ByRichard C. Gehrz

chapter 14|14 pages

14Interferons and Epstein-Barr Virus Infection

ByMotohiko Okano, David T. Purtilo

chapter 15|24 pages

Treatment of Lepromatous Leprosy with Recombinant Interferon-Gamma

ByCarl F. Nathan

chapter 16|14 pages

Interferon-Gamma and the Control of Intracellular Chlamydia Replication

ByGerald I. Byrne, Julius Schachter

chapter 17|14 pages

Influence of Interferon-Gamma on Legionella pneumophila

Mononuclear Phagocyte Interaction
ByMarcus A. Horwitz

chapter 18|14 pages

Interferon-Gamma and Fungal Infections

ByDavid A. Stevens

part III|16 pages

Target Treatment Strategies

chapter 19|14 pages

Interferon-Gamma as an Adjuvant for Vaccines

ByA.W. Heath, J.H.L. Playfair