ABSTRACT

Offering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell leukemia, non-Hodgkin's lymphoma, membranous nephropathy, and rheumatoid and psoriatic arthritis.

chapter 2|36 pages

Induction of Apoptosis by Nucleoside Analogs

ByPeng Huang, Susan Wright

chapter 3|21 pages

Pharmacokinetics of Purine Nucleoside Analogs

ByJan Liliemark, Gunnar Juliusson

chapter 4|18 pages

Clinical Development of 2′-Deoxycoformycin

ByBruce D. Cheson, Michael R. Grever

chapter 5|46 pages

Clinical Development of Fludarabine

ByAxel-R. Hanauske, Daniel D. Von Hoff

chapter 6|15 pages

Development of 2-Chlorodeoxyadenosine (2-CdA) as a Chemotherapeutic and Immunosuppressive Drug

ByErnest Beutler, Robert McMillan, Dennis Carson, Robert Longmire

chapter 7|26 pages

Defining the Optimal Dose Schedule of Purine Analogs and Assessment of Response

ByJorge E. Cortes, Susan M. O’Brien

chapter 8|26 pages

Clinical Trials of the Purine Analogs in Chronic Lymphocytic Leukemia

ByMichael J. Keating

chapter 9|20 pages

Treatment of Hairy Cell Leukemia with Nucleoside Analogs

ByAlan Saven, Lawrence D. Piro

chapter 10|42 pages

Clinical Trials with Nucleoside Analogs in Lymphomas

ByWolfgang Hiddemann, Christiane Pott-Hoeck

chapter 11|26 pages

Clinical Trials with Nucleoside Analogs in Other Hematologic Malignancies

ByJorge E. Cortes, Hagop Kantarjian, Susan M. O’Brien, Michael J. Keating

chapter 12|44 pages

Nucleoside Analogs as Radiosensitizing Agents

ByVincent Grégoire, Walter N. Hittelman

chapter 13|24 pages

2-Chlorodeoxyadenosine in Nonmalignant Disorders

ByErnest Beutler, Dennis Carson, J. C. Sipe, J. S. Romine, Robert McMillan, Z. M. Younossi, V. D. Rodgers, James A. Koziol, J. Zyroff

chapter 14|31 pages

Fludarabine in Nonmalignant Disorders

ByIoannis O. Tassiulas, John C. Davis, Barri J. Fessler, Nobuaki Hama, Thomas A. Fleisher, Howard A. Austin, Dimitrios T. Boumpas

chapter 15|45 pages

Toxicities Associated with Purine Analog Therapy

ByBruce D. Cheson