ABSTRACT

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

part Part I|153 pages

Biology of Skin and Hair of Laboratory Mice and Human Beings

chapter 1|4 pages

Applications and Needs of Models for Dermatological Research

ByLowell A. Goldsmith

chapter 3|8 pages

The Jackson Laboratory Mouse Mutant Resource

ByMuriel T. Davisson

chapter 4|10 pages

Hair Follicle Stem Cells

ByRobert M. Lavker, Tung-Tien Sun, John P. Sundberg

chapter 5|8 pages

The Mouse Skin as a Model for Chemical Carcinogenesis

ByClaudio J. Conti

chapter 6|9 pages

Viral Induced Skin Tumors in Mice

ByJohn P. Sundberg, Hendrick G. Bedigian, Roderick Bronson

chapter 7|12 pages

Hair Types and Subtypes in the Laboratory Mouse

ByJohn P. Sundberg, Margaret E. Hogan

chapter 8|11 pages

Growth Factors and Cutaneous Pathology

ByLloyd E. King, Lillian B. Nanney, Ronald E. Gates

chapter 9|14 pages

Transgenic Mice with Cytokine Mutations Affecting the Skin

ByManfred Blessing, Erby Wilkinson, Brigid L. M. Hogan

chapter 10|10 pages

Epidermal Keratins

ByJoseph A. Rothnagel, Dennis R. Roop

chapter 11|12 pages

Hair Follicle Keratins

ByGeorge E. Rogers, Barry C. Powell

chapter 12|11 pages

Keratinocyte Cultures as Models for Dermatological Disease

ByMark R. Pittelkow

chapter 13|13 pages

Mouse Mutations with Endocrine Functional Consequences

ByWesley G. Beamer

part Part II|378 pages

Animal Models of Genetic Based Skin Diseases

section Section A|325 pages

Mouse Single Gene Mutations

chapter 1|6 pages

The Adrenocortical Dysplasia (acd) Mutation, Chromosome 8

ByJohn P. Sundberg, Seth J. Orlow, Hope O. Sweet, Wesley G. Beamer

chapter 2|6 pages

The Angora (go) Mutation, Chromosome 5

ByJohn P. Sundberg

chapter 3|7 pages

The Asebia (ab, abJ) Mutations, Chromosome 19

ByJohn P. Sundberg

chapter 4|7 pages

The Atrichosis (at) Mutation, Chromosome 10

ByJohn P. Sundberg

chapter 5|5 pages

The Balding (bal) Mutation, Chromosome 18

ByJohn P. Sundberg

chapter 6|3 pages

The Bare-Patches (Bpa) Mutation, Chromosome X

ByJohn P. Sundberg

chapter 7|6 pages

The Bareskin (Bsk) Mutation, Chromosome 11

ByJohn P. Sundberg

chapter 8|8 pages

The Beige (bg) Mutation, Chromosome 13

ByJohn P. Sundberg

chapter 9|6 pages

The Caracul (Ca and Cad) Mutations, Chromosome 15

ByJohn P. Sundberg, Hope O. Sweet

chapter 10|4 pages

The Chronic Proliferative Dermatitis (cpd) Mutation, Chromosome ?

ByHarm HogenEsch, Marion J. J. Gijbels, Chris Zurcher

chapter 11|9 pages

The Crinkled (cr) Mutation, Chromosome 13

ByJohn P. Sundberg

chapter 12|4 pages

The Curly-Whiskers (cw) Mutation, Chromosome 9

ByJohn P. Sundberg

chapter 13|6 pages

The Depilated (dep) Mutation, Chromosome 4

ByJohn P. Sundberg, Seth J. Orlow

chapter 14|6 pages

The Downless (dl) and Sleek (Dlslk) Mutations, Chromosome 10

ByJohn P. Sundberg

chapter 15|5 pages

The Ferrochelatase Deficiency (Fechm1Pas) Mutation, Chromosome 18

ByXavier Montagutelli

chapter 16|16 pages

The Flaky Skin (fsn) Mutation, Chromosome ?

ByJohn P. Sundberg, Dawnalyn Boggess, Leonard D. Shultz, Wesley G. Beamer

chapter 17|5 pages

The Flaky Tail (ft) Mutation, Chromosome 3

ByJohn P. Sundberg

chapter 18|4 pages

The Frizzy (fr) Mutation, Chromosome 7

ByJohn P. Sundberg

chapter 19|5 pages

The Fuzzy (fz) Mutation, Chromosome 1

ByJohn P. Sundberg

chapter 20|4 pages

The Greasy (Gs) Mutation, Chromosome X

ByJohn P. Sundberg

chapter 21|2 pages

The Hair Interior Defect (hid) Mutation, Chromosome ?

ByJohn P. Sundberg

chapter 22|22 pages

The Hairless (hr) and Rhino (hrrh) Mutations, Chromosome 14

ByJohn P. Sundberg

chapter 23|5 pages

The Hair Patches (Hpt) Mutation, Chromosome 4

ByJohn P. Sundberg

chapter 24|4 pages

The Hairy Ears (Eh) Mutation, Chromosome 15

ByJohn P. Sundberg, Seth J. Orlow

chapter 25|4 pages

The Harlequin (Hq) Mutation, Chromosome X

ByJohn P. Sundberg

chapter 26|9 pages

The Ichthyosis (ic) Mutation, Chromosome 1

ByJohn P. Sundberg, Mark R. Pittelkow

chapter 27|6 pages

The Lethal Milk (lm) Mutation, Chromosome 2

ByJohn P. Sundberg, Hope O. Sweet

chapter 28|2 pages

The Lustrous (It) Mutation, Chromosome 11

ByJohn P. Sundberg

chapter 29|5 pages

The Matted (ma) Mutation, Chromosome 3

ByJohn P. Sundberg

chapter 30|8 pages

The Motheaten (me) and Viable Motheaten (mev) Mutations, Chromosome 6

ByLeonard D. Shultz, John P. Sundberg

chapter 32|7 pages

The Naked (N) Mutation, Chromosome 15

ByJohn P. Sundberg

chapter 33|11 pages

The Nude (nu) and Streaker (nustr) Mutations, Chromosome 11

ByJohn P. Sundberg

chapter 34|7 pages

The Ragged (Ra) and Opossum (Raop) Mutations, Chromosome 2

ByJohn P. Sundberg

chapter 35|7 pages

The Repeated Epilation (Er) Mutation, Chromosome 4

ByJean-Louis Guénet, Josselyne Salaun, Berthe Salzgeber

chapter 37|4 pages

The Satin (sa) Mutation, Chromosome 13

ByJohn P. Sundberg

chapter 38|6 pages

The Scurfy (sf) Mutation, Chromosome X

ByVirginia L. Godfrey

chapter 39|7 pages

The Severe Combined Immunodeficiency (scid) Mutation, Chromosome 16

ByJohn P. Sundberg, Leonard D. Shultz

chapter 40|5 pages

The Shaven (Sha) Mutation, Chromosome 15

ByJohn P. Sundberg

chapter 41|5 pages

The Silver (si) Mutation, Chromosome 10

BySeth J. Orlow, John P. Sundberg

chapter 42|3 pages

The Soft Coat (soc) Mutation, Chromosome 3

ByJohn P. Sundberg

chapter 43|2 pages

The Sparse-Coat (spc) Mutation, Chromosome 14

ByJohn P. Sundberg

chapter 44|5 pages

The Sparse-Fur (Otcspf) and Abnormal Skin and Hair (Otcash) Mutations, Chromosome X

ByJohn P. Sundberg, Donald P. Doolittle

chapter 46|8 pages

The Tight-Skin (Tsk) Mutation, Chromosome 2

ByJohn P. Sundberg

chapter 47|4 pages

The Vitiligo (mivit) Mutant Allele of the Microphthalmia Locus, Chromosome 6

ByM. Lynn Lamoreux, Seth J. Orlow

chapter 48|5 pages

The Wellhaarig (we, weBkr) Mutations, Chromosome 2

ByJohn P. Sundberg

section Section B|25 pages

Purported Polygenic Mouse Skin Diseases

chapter 1|8 pages

Chronic Ulcerative Dermatitis in Black Mice

ByJohn P. Sundberg, Kathy S. Brown, William M. McMahon

chapter 2|5 pages

Barbering Behavioral Abnormalities in Inbred Laboratory Mice

ByWilliam M. McMahon, John P. Sundberg

chapter 3|7 pages

Alopecia Areata in Aging C3H/HeJ Mice

ByJohn P. Sundberg, Colleen M. Vallee, Lloyd E. King

section Section C|26 pages

Nonmurine Animal Models of Genetic Based Skin Diseases

chapter 1|24 pages

Selected Heritable Skin Diseases of Domesticated Animals

ByRobert W. Dunstan, Robert A. Kennis