ABSTRACT

A review of what needs to be done to realise the potential of monoclonal antibodies. The book assesses the competing technologies with advice on the best approach for a particular situation.

chapter Chapter 1|13 pages

Introduction

ByHeddy Zola

chapter Chapter 2|28 pages

Making and using ‘conventional' mouse monoclonal antibodies

ByPeter J. Donohoe, Peter J. Macardle, Heddy Zola

chapter Chapter 3|24 pages

Human monoclonal antibodies from immortalized B cells

ByArthur W. Hohmann, Linda Spatz, Macarena Irigoyen, Audrey Manheimer-Lory

chapter Chapter 4|26 pages

Reconstruction of monoclonal antibodies by genetic engineering

ByJohn R. Adair, David J. King

chapter Chapter 5|25 pages

The genetic engineering of antibody constructs for diagnosis and therapy

ByGeoffrey A. Pietersz, Ian F.C. McKenzie

chapter Chapter 6|21 pages

Superseding hybridoma technology with phage display libraries

ByRobert Irving, Peter Hudson

chapter Chapter 7|24 pages

Construction and application of libraries of artificial antibodies

ByWataru Ito, Yoshikazu Kurosawa

chapter Chapter 8|17 pages

Expression of antibody genes in mammalian cells

ByChristopher Bebbington