In 2021, over 537 million people worldwide were diagnosed with diabetes, according to the International Diabetes Federation and so the diagnosis, care and treatment of patients with diabetes mellitus have become one of the highest healthcare priorities. Biomedical photonics methods have been found to significantly improve and assist in the diagnosis of various disorders and complications arising from diabetes. These methods have also been widely used in various studies in the field of diabetes, including in the assessment of biochemical characteristics, metabolic processes, and microcirculation that are impaired in this disease.

This book provides an introduction to methods of biomedical photonics. The chapters, written by world-leading experts, cover a wide range of issues, including the theoretical basis of different biophotonics methods and practical issues concerning the conduction of experimental studies to diagnose disorders associated with diabetes. It provides a comprehensive summary of the recent advances in biomedical optics and photonics in the study of diabetes and related complications.

This book will be of interest to biomedical physicists and researchers, in addition to practicing doctors and endocrinologists looking to explore new instrumental methods for monitoring the effectiveness of patient treatment.


• The first collective book combining accumulated knowledge and experience in the field of diabetes research using biophotonics.

• Contributions from leading experts in the field.

• Combines the theoretical base of the described methods and approaches, as well as providing valuable practical guidance and the latest research from experimental studies.

chapter 1|31 pages

Optical and Structural Properties of Biological Tissues under Simulated Diabetes Mellitus Conditions

ByDaria K. Tuchina, Alla B. Bucharskaya, Polina A. Dyachenko (Timoshina), Nataliya I. Dikht, Georgy S. Terentyuk, Valery V. Tuchin

chapter 2|24 pages

Optical Methods for Diabetic Foot Ulcer Screening

ByRobert Bartlett, Gennadi Saiko, Alexandre Yu. Douplik

chapter 3|23 pages

The Use of Capillaroscopy and Aggregometry Methods to Diagnose the Alterations of Microcirculation and Microrheology in Diabetes

ByAndrei E. Lugovtsov, Yury I. Gurfinkel, Petr B. Ermolinskiy, Anastasia A. Fabrichnova, Alexander V. Priezzhev

chapter 4|25 pages

Diagnostics of Functional Abnormalities in the Microcirculation System Using Laser Doppler Flowmetry

ByIrina A. Mizeva, Elena V. Potapova, Elena V. Zharkikh

chapter 5|29 pages

Wearable Sensors for Blood Perfusion Monitoring in Patients with Diabetes Mellitus

ByEvgenii A. Zherebtsov, Elena V. Zharkikh, Yulia I. Loktionova, Angelina I. Zherebtsova, Viktor V. Sidorov, Alexander I. Krupatkin, Andrey V. Dunaev

chapter 6|18 pages

Optical Angiography at Diabetes

ByDan Zhu, Jingtan Zhu, Dongyu Li, Tingting Yu, Wei Feng, Rui Shi

chapter 7|22 pages

Noninvasive Sensing of Serum sRAGE and Glycated Hemoglobin by Skin UV-Induced Fluorescence

ByVladimir V. Salmin, Tatyana E. Taranushenko, Natalya G. Kiseleva, Alla B. Salmina

chapter 8|19 pages

Hyperspectral Imaging of Diabetes Mellitus Skin Complications

ByViktor V. Dremin, Evgenii A. Zherebtsov, Alexey P. Popov, Igor V. Meglinski, Alexander V. Bykov

chapter 9|16 pages

Fluorescent Technology in the Assessment of Metabolic Disorders in Diabetes

ByElena V. Zharkikh, Viktor V. Dremin, Andrey V. Dunaev

chapter 10|25 pages

Terahertz Time-Domain Spectroscopy in the Assessment of Diabetic Complications

BySviatoslav I. Gusev, Ravshanjon Kh. Nazarov, Petr S. Demchenko, Tianmiao Zhang, Olga P. Cherkasova, Mikhail K. Khodzitsky

chapter 11|15 pages

Noninvasive Photonic Sensing of Glucose in Bloodstream

ByNisan Ozana, Zeev Zalevsky