ABSTRACT

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. 

The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. 

This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

part Part I|72 pages

Fundamentals

chapter Chapter 1|5 pages

Recent Trends in Nanotechnology for Brain Delivery: A Brief Outlook

ByCarla Vitorino, Andreia Jorge, Alberto Pais

chapter Chapter 2|30 pages

Understanding Brain Delivery

ByJoana Bicker, Ana Fortuna, Gilberto Alves, Amílcar Falcäo

chapter Chapter 3|34 pages

Novel Routes to Accessing the Brain: Intranasal Administration

ByAna Serralheiro, Joana Bicker, Gilberto Alves, Amílcar Falcäo, Ana Fortuna

part Part II|275 pages

Nanomedicines

chapter Chapter 4|86 pages

Organic Nanocarriers for Brain Drug Delivery

ByMarlene Lúcio, Carla M. Lopes, Eduarda Fernandes, Hugo Gonẹalves, Maria Elisabete C. D. Real Oliveira

chapter Chapter 5|28 pages

Magnetic and Plasmonic Nanoparticles for Brain Drug Delivery

ByAna Luísa Daniel-da-Silva

chapter Chapter 6|22 pages

Hybrid Nanosystems

ByPablo Vicente Torres-Ortega, Laura Saludas, Jon Eneko Idoyaga, Carlos Rodríguez-Nogales, Elisa Garbayo, María José Blanco-Prieto

chapter Chapter 7|45 pages

Drug Nanocrystals

ByM. Ermelinda S. Eusébio, Ricardo A. E. Castro, Joäo Canotilho

chapter Chapter 8|31 pages

Lipid Nanocarriers for Oligonucleotide Delivery to the Brain

ByAndreia F. Jorge, Santiago Grijalvo, Alberto Pais, Ramón Eritja

chapter Chapter 9|28 pages

Carriers for Nucleic Acid Delivery to the Brain

BySören Reinhard, Ernst Wagner

chapter Chapter 10|31 pages

Advances in Nanotheranostics with Plasmonic and Magnetic Nanoparticles

BySérgio R. S. Veloso, Paula M. T. Ferreira, J. A. Martins, Paulo J. G. Coutinho, Elisabete M. S. Castanheira

part Chapter Part III|123 pages

Development and Translahon

chapter Chapter 11|32 pages

Quality by Design for Nanocarriers

ByBranca M. A. Silva, Cláudia Silva

chapter Chapter 12|23 pages

Recent in vitro Models for the Blood-Brain Barrier

ByJoão Basso, Maria Mendes, Maria Ferreira, João Sousa, Alberto Pais, Carla Vitorino

chapter Chapter 13|19 pages

Current in vivo Models for Brain Disorders

ByMarta Guerra-Rebollo, Cristina Garrido

chapter Chapter 14|25 pages

Modelling and Simulation of Nanosystems for Delivering Drugs to the Brain

ByTânia F. G. G. Cova, Sandra C.C. Nunes

chapter Chapter 15|19 pages

Translational Challenges

ByBárbara Rocha, Nelson Pacheco Rocha, Bruno Gago