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      Advances in Medical Biochemistry, Genomics, Physiology, and Pathology
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      Book

      Advances in Medical Biochemistry, Genomics, Physiology, and Pathology

      DOI link for Advances in Medical Biochemistry, Genomics, Physiology, and Pathology

      Advances in Medical Biochemistry, Genomics, Physiology, and Pathology book

      Advances in Medical Biochemistry, Genomics, Physiology, and Pathology

      DOI link for Advances in Medical Biochemistry, Genomics, Physiology, and Pathology

      Advances in Medical Biochemistry, Genomics, Physiology, and Pathology book

      Edited ByRaj Bawa, Esther H. Chang, Gerald F. Audette, Anil Diwan, Saadia A. Faiz
      Edition 1st Edition
      First Published 2021
      eBook Published 23 December 2021
      Pub. Location New York
      Imprint Jenny Stanford Publishing
      DOI https://doi.org/10.1201/9781003180449
      Pages 696
      eBook ISBN 9781003180449
      Subjects Bioscience, Engineering & Technology, Medicine, Dentistry, Nursing & Allied Health
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      Bawa, R., Chang, E.H., Audette, G.F., Diwan, A., & Faiz, S.A. (Eds.). (2021). Advances in Medical Biochemistry, Genomics, Physiology, and Pathology (1st ed.). Jenny Stanford Publishing. https://doi.org/10.1201/9781003180449

      ABSTRACT

      The pace and sophistication of advances in medicine in the past two decades have necessitated a growing need for a comprehensive reference that highlights current issues in medicine. Each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various critical topics—all accomplished in a user-friendly yet interconnected format. The series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies. While bridging the gap between basic research and clinical medicine, this series provides a thorough understanding of medicine’s potential to address health problems from both the patient’s and the provider’s perspectives in a healthcare setting. The range of topics covered and the expertise of the contributing authors accurately reflect the rapidly evolving areas within medicine—from basic medical sciences to clinical specialties. Each volume is essential reading for physicians, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, policymakers, and biomedical researchers. The multidisciplinary approach of the series makes it a valuable reference resource for the pharmaceutical industry, academia, and governments. However, unlike other series on medicine or medical textbooks, this series focuses on current trends, perspectives, and issues in medicine that are central to healthcare delivery in the 21st century. Volume 1 focuses on the current issues in basic medical sciences, subjects that are fundamental to the practice of medicine. Specifically, it covers medical biochemistry, genomics, physiology, and pathology. These subjects, traditionally taught in the first two years of medical school that precede clinical instruction, provide a core of basic knowledge critical to the success in clinical medicine during rotations, training, and medical practice.

      TABLE OF CONTENTS

      chapter |5 pages

      Engraving: marble bust of Hippocrates; by A. Mecou after Vauthier after a statue in the Louvre, n.d. Library reference no.: Burgess, Portraits, 1403.5. This bust is a typical portrayal of Hippocrates—as an experienced and wise old man. Kindly provided by Wellcome Library, London.

      ByRaj Bawa, Esther H. Chang, Gerald F. Audette, Anil Diwan, Saadia A. Faiz

      chapter Chapter 1|51 pages

      The Age of COVID-19: Medical Facts and Fiction

      ByRaj Bawa

      part Section 1|428 pages

      Medical Biochemistry and Genomics

      chapter Chapter 2|35 pages

      Role of Engineered Proteins as Therapeutic Formulations

      ByKhushboo Gulati, Krishna Mohan Poluri

      chapter Chapter 3|20 pages

      How Physical and Chemical Information Predicts the Action of Molecules: A Historical Overview

      ByMyron L. Toews, JoEllyn M. McMillan, David B. Bylund

      chapter Chapter 4|26 pages

      Three-Dimensional Chromatin in Infectious Disease: A Role for Gene Regulation and Pathogenicity?

      BySage Z. Davis, Thomas Hollin, Todd Lenz, Karine G. Le Roch

      chapter Chapter 5|33 pages

      Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

      ByZhaoying Fu, Jim Xiang

      chapter Chapter 6|24 pages

      Identifying Genetic Markers Associated with Susceptibility to Cardiovascular Diseases

      ByHitesh Shukla, Jessica Louise Mason, Abdullah Sabyah

      chapter Chapter 7|23 pages

      Production and Application of Multicistronic Constructs for Various Human Disease Therapies

      ByAlisa A. Shaimardonova, Daria S. Chulpanova, Kristina V. Kitaeva, Ilmira I. Abdrakhmanova, Vladislav M. Chernov, Catrin S. Rutland, Albert A. Rizvanov, Valeriya V. Solovyeva

      chapter Chapter 8|31 pages

      The Nuclear Lamina: Protein Accumulation and Disease

      ByCarla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Tray A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw

      chapter Chapter 9|51 pages

      The Importance of Protein Post-Translational Modifications in the Pathogenesis and Progression of Neurodegenerative Diseases

      ByLarissa-Nele Schaffert, Wayne G. Carter

      chapter Chapter 10|31 pages

      DNA Damage/Repair Management in Cancers

      ByJehad F. Alhmoud, John F. Woolley, Ala-Eddin Al Moustafa, Mohammed Imad Mallei

      chapter Chapter 11|24 pages

      Advancing Clinical Cohort Selection with Genomics Analysis on a Distributed Platform

      ByJaclyn M. Smith, Melvin Lathara, Hollis Wright, Nalini Ganapati, Ganapati Srinivasa, Christopher T. Denny

      chapter Chapter 12|10 pages

      Pharmacogenomics of Tamoxifen

      ByHitoshi Zembutsu

      chapter Chapter 13|29 pages

      Nanocrystals: The Universal Formulation Principle to Improve the Bioactivity of Poorly Soluble Actives

      ByRalph W. Eckert, Steffen F. Hartmann, Daniel Knoth, Olga Pelikh, Rainer H. Müller, Cornelia M. Keck

      chapter Chapter 14|20 pages

      Cellular Mechanisms of Human Atherogenesis: Focus on Chronification of Inflammation and Mitochondrial Mutations

      ByAlexander M. Markin, Igor A. Sobenin, Andrey V. Grechko, Dongwei Zhang, Alexander N. Orkhov

      chapter Chapter 15|14 pages

      Vitamin D Pathway and the Pathogenesis of Inflammatory Bowel Disease

      ByStefano Nobile, Michela A. Tenace, Helen M. Pappa

      chapter Chapter 16|17 pages

      The Structural Ensemble of the Conjugative F-like T4SS

      ByNicholas Bragagnolo, Christina Rodriguez, Gerald F. Audette

      chapter Chapter 17|16 pages

      Polygenic Risk-Tailored Screening for Prostate Cancer: A Benefit–Harm and Cost-Effectiveness Modelling Study

      ByTom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, D. P. Paul Pharoah, Nora Pashayan

      chapter Chapter 18|14 pages

      Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication

      ByMichela Battistelli, Elisabetta Falcieri

      part Section 2|161 pages

      Human Physiology and Pathology

      chapter Chapter 19|20 pages

      Circulating Tumor Cells and Personalized Medicine

      ByJin Sun Lee, Mark Jesus M. Magbanua, Marc R. Jabon, John W. Park

      chapter Chapter 20|9 pages

      Pathology in the Era of Personalized Medicine

      ByHye Seung Lee

      chapter Chapter 21|17 pages

      Speech Intelligibility during Clinical and Low Frequency

      ByJohn J. Sidtis, Diana Van Lancker Sidtis, Ritesh Ramdhani, Michele Tagliati

      chapter Chapter 22|4 pages

      Physiological Renormalization Using Systems Therapeutics

      ByGreg Maguire

      chapter Chapter 23|4 pages

      Pathology Is Always Around Us: Apophenia in Pathology, a Remarkable Unreported Phenomenon

      ByAhmed S. Sultan, Maryam Jessri

      chapter Chapter 24|19 pages

      The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?

      ByAlessandra Mazzocchi, Ludovica Leone, Carlo Agostoni, Isabella Pali-Schöll

      chapter Chapter 25|20 pages

      Relationship between Diet, Microbiota, and Healthy Aging

      ByJuan Gambini, Elisa Sanchez-Morate, Lucia Gimeno-Mallench, Kristine Stromsnes, Jorge Sanz-Ros, Aurora Román-Domínguez, Sergi Parejo-Pedrajas, Marta Inglés, Gloria Olaso, Cristina Mas-Bargues

      chapter Chapter 26|17 pages

      Does Low-Density Lipoprotein Cholesterol Induce Inflammation? If So, Does It Matter? Current Insights and Future Perspectives for Novel Therapies

      ByRuurt A. Jukema, Tarek Ahmed, Jean-Claude Tardif

      chapter Chapter 27|14 pages

      Role of Biomarkers in Clinical Development of Cancer Therapies

      ByHelen X. Chen

      chapter Chapter 28|12 pages

      In Sickness and Health: Effects of Gut Microbial Metabolites on Human Physiology

      ByRobert W. P. Glowacki, Eric C. Martens

      chapter Chapter 29|9 pages

      Current Methodologies Utilized in the Conduct of Randomized Clinical Trials

      ByMarina A. Malikova

      chapter Chapter 30|9 pages

      The Prion-Like Phenomenon in Alzheimer's Disease: Evidence of Pathology Transmission in Humans

      ByRuben Gomez-Gutierrez, Rodrigo Morales
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