Gene delivery is a transport of genes of therapeutic values into the chromosomes of the cells or tissues which can be targeted to replace the faulty genes. In last two decades lot of research efforts are dedicated to gene delivery for therapeutic applications. Today gene therapy is promising approach in treatment of genetic diseases including mitochondrial related diseases like blindness, muscular dystrophy, cystic fibrosis, and some cancers.

Gene Delivery Systems: Nano Delivery Technologies observes the exploration of nanotechnology for gene therapy and gene delivery. Written by prominent authors in the field, this book covers various aspects of gene delivery including challenges in delivering gene therapy, advances in genome editing, RNA-based gene therapy, Green nanoparticles for oligonucleotide delivery.

Additional features include"

  • Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing.
  • Includes knowledge of the current application of CRISPR/Cas9 gene-editing technique; an approach that has recently been given the Noble Prize.
  • Examines the development of mRNA vaccines for Covid -19 in challenging pandemic scenario
  • Discusses siRNA, mRNA, and DNA plasmids.


chapter 1|13 pages

Challenges in Delivering Gene Therapy

ByDivya Sheth, Yashwant Pathak

chapter 2|16 pages

Advances in Genome Editing

The Technology of Choice for Precise and Efficient Disease Treatment, with Special Focus on Nano Delivery Systems
ByKomal Parmar, Jayvadan Patel

chapter 3|20 pages

Extracellular Vesicles for Nucleic Acid Delivery

Progress and Prospects for Safe RNA-Based Gene Therapy
ByMd Meraj Anjum, Dulla Naveen Kumar, Aiswarya Chaudhuri, Sanjay Singh, Ashish Kumar Agrawal

chapter 4|14 pages

Green Synthesis of Nanoparticles in Oligonucleotide Drug Delivery System

ByManish P. Patel, Praful D. Bharadia, Kunjan B. Bodiwala, Mustakim M. Mansuri, Jayvadan Patel

chapter 5|6 pages

Development of m-RNA Vaccines in Covid-19 Pandemic Scenario

ByDisha Jain, Yashwant Pathak

chapter 6|14 pages

Gene Therapy for Cardiovascular Diseases

Clinical Evidences
ByDhwani Thakkar, Vandit Shah, Jigna Shah

chapter 7|17 pages

Current Application of CRISPR/Cas9 Gene-Editing Technique to Eradication of HIV/AIDS

ByPrachi Pandey, Jayvadan Patel, Samarth Kumar

chapter 8|11 pages

siRNA Delivery for Therapeutic Applications Using Nanoparticles

BySonia Barua, Yashwant Pathak

chapter 9|14 pages

Clinical Perspectives on Gene Therapy for Retinal and Eye Diseases

ByDevika S. Joshi, Gaurav M. Karve, Shrikant D. Joshi

chapter 10|10 pages

Herpesvirus microRNAs for Use in Gene Therapy Immune-Evasion Strategies

ByVineet Mahajan, Shruti Saptarshi, Yashwant Pathak

chapter 11|23 pages

Gene Therapy and Small Molecules Used in the Treatment of Cystic Fibrosis

ByManish P. Patel, Uma G. Daryai, Mansi N. Athalye, Praful D. Bharadia, Jayvadan Patel

chapter 12|15 pages

Non-Viral Delivery of Genome-Editing Nucleases for Gene Therapy

BySonia Barua, Yashwant Pathak

chapter 13|16 pages

CRISPER Gene Therapy Recent Trends and Clinical Applications

ByPrachi Pandey, Jayvadan Patel, Samarth Kumar

chapter 14|12 pages

Clinical Applications of Gene Therapy for Immuno-Deficiencies

ByKhushboo Faldu, Sakshi Gurbani, Jigna Shah

chapter 15|14 pages

Regulatory Challenges for Gene Delivery

ByVineet Mahajan, Shruti Saptarshi, Yashwant Pathak