ABSTRACT
Biologically Active Small Molecules: Modern Applications and Therapeutic Perspectives focuses on small molecules as active pharmacological agents, their pharmacotherapeutically active properties, new approaches in drug discovery using small molecules, and biopharmaceutic approaches for low molecular weight ligands.
Molecules of low mass play a pivotal role in pharmacology because they exhibit multifarious pharmacological effects. Small molecules have become universally popular due to their simple chemistry, easy separation techniques, versatile acceptance for computational studies, large number of places for the substitution of active chemical moieties by well-established synthetic routes with less effort, better quality attributes, and ability to demonstrate numerous biological activities.
This book provides a multidisciplinary approach that delivers the most updated knowledge and advances of some newly developed therapeutically active low molecular weight compounds. It includes chapters that present up-to-date and concise content on the classification, structures, chemical syntheses, medicinal chemistry, pharmacology, biochemical pathways, mechanism of actions, side effects, and adverse effects of small molecule drug discovery. The book covers a broad area by highlighting the advances of inter- and multidisciplinary fields of medicine, chemical sciences, and pharmaceuticals. The flowcharts, figures, illustrations, and diagrams provide important information and will be of great interest for readers.
TABLE OF CONTENTS
part I|84 pages
Small Molecules as Active Pharmacological Agents
chapter Chapter 3|14 pages
Perspectives of Chalcone-Based Nf-Kβ Inhibitors as Anti-Inflammatory Agents
part II|160 pages
Pharmacotherapeutically Active Classes
part III|40 pages
Modern Approaches in Small Molecule Drug Discovery
chapter Chapter 10|11 pages
Biological Databases: Tool for Low Molecular Weight Ligand Discovery Process
chapter Chapter 11|13 pages
High-Throughput Screening Technique: Role in the Drug Discovery of Low Molecular Weight Ligands
chapter Chapter 12|12 pages
Homology Modeling: Applications in the Low Molecular Weight Ligand Designing
part IV|64 pages
Biopharmaceutics Approaches for Low Molecular Weight Ligands
chapter Chapter 14|16 pages
Drug Interactions: Highlights of Adverse Effects of Low Molecular Weight Ligands
part V|12 pages
Evaluation Methods for Small Molecules