Pharmaceutical Dosage Forms: Capsules covers the development, composition, and manufacture of capsules. Despite the important role that capsules play in drug delivery and product development, few comprehensive texts on the science and technology of capsules have been available for the research and academic environments. This text addresses this gap, discussing how capsules provide unique capabilities and options for dosage form design and formulation.

chapter 1|14 pages

Advances in Capsule Formulation Development and Technology

ByLarry L. Augsburger, Stephen W. Hoag

chapter 2|16 pages

An Introduction to Two-Piece Hard Capsules and Their Marketing Benefits

ByDennis Murachanian

chapter 3|44 pages

Hard Shell Capsules in Clinical Trials

ByMoji Christianah Adeyeye, Amusa Adebayo

chapter 4|36 pages

Capsule Shell Manufacture

ByBrian E. Jones, Fridrun Podczeck, Paul Lukas

chapter 5|20 pages

Non-Gelatin-Based Capsules

BySven Stegemann

chapter 6|60 pages

Hard Shell Capsule Filling Machines

ByDonald K. Lightfoot

chapter 7|20 pages

Instrumented Automatic Capsule Filling Machines and Filling Machine Simulation

ByLarry L. Augsburger, Vikas Moolchandani

chapter 8|26 pages

Dry-Fill Formulation and Filling Technology

ByPavan Heda, Vikas Agarwal, Shailesh K. Singh

chapter 9|46 pages

Plug Formation

ByFridrun Podczeck

chapter 10|24 pages

Modeling Powder Filling during Encapsulation

ByAmmar Khawam

chapter 11|10 pages

Scale-Up and Transfer of Hard Shell Formulations across Machine Types

ByLarry L. Augsburger, Michael Levin

chapter 12|28 pages

Modified-Release Delivery Systems

Extended-Release Capsule Platform
ByReza Fassihi

chapter 13|28 pages

Analytical Testing and Evaluation of Capsules

ByStuart L. Cantor, Asish K. Dutta

chapter 15|22 pages

Quality-by-Design (QbD) for Capsule Formulation and Process Development

Regulatory Science Relevance, Scientific Case Studies, and Future Challenges 1
ByHuiquan Wu, Lin Xie, Stephen W. Hoag, Larry L. Augsburger, Mansoor Khan