Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery.

This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore, a timely unique encyclopaedia on cobalamin.

chapter 1|29 pages

Milestones in the Discovery of Pernicious Anemia and its Treatment

ByJörn Schneede

chapter 3|48 pages

Intracellular Processing and Utilization of Cobalamins

ByLuciana Hannibal, Donald W Jacobsen

chapter 4|21 pages

Inherited Defects of Cobalamin Metabolism

ByDavid Watkins, David S. Rosenblatt

chapter 6|20 pages

Vitamin B12 Deficiency in Developing and Newly Industrialising Countries

ByChittaranjan Yajnik, Urmila Deshmukh, Prachi Katre, Tejas Limaye

chapter 7|27 pages

Vitamin B12 in Neurology and Aging

ByAndrew McCaddon, Joshua W Miller

chapter 9|51 pages

Laboratory Markers and Diagnosis of Cobalamin Deficiency

ByRima Obeid

chapter 10|25 pages

Cobalamin During Pregnancy and Lactation

ByRima Obeid, Pol Solé-Navais, Michelle M Murphy

chapter 11|31 pages

Vitamin B12 After Birth and During Early Life

ByRima Obeid, Pol Solé-Navais, Michelle M Murphy

chapter 12|21 pages

Cobalamin—Folate Interactions

ByPol Solé-Navais, Rima Obeid, Michelle M Murphy

chapter 14|27 pages

Vitamin B12 and Drug Development

ByJayme L Workinger, Robert P Doyle