Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.

chapter 1|48 pages

Recombinant Antibodies

Construction and Production
ByMelvyn Little, Sergey M. Kipriyanov

chapter 2|32 pages

Bispecific Antibodies

ByDavid M. Segal, Barbara A. Vance, Giuseppe Sconocchia

chapter 3|34 pages

Targeted Cytotoxicity

Antibody-Drug and Antibody-Toxin Conjugates
ByUwe Zangemeister-Wittke, Winfried Wels

chapter 4|20 pages

Selective Drug Delivery Using Targeted Enzymes For Prodrug Activation

ByNathan O. Siemers, Peter D. Senter

chapter 5|24 pages

Immunoscintigraphy and Radioimmunotherapy

ByAngelika Bischof Delaloye

chapter 6|44 pages

Clinical Studies In Oncology

ByJan Schmielau, Wolff Schmiegel

chapter 7|52 pages

Clinical Studies In Acute and Chronic Inflammation

ByJanice C. Wherry

chapter 8|50 pages

Marrow Purging And Stem Cell Preparation

ByDenis C. Roy, Nadine Beauger, Martin Gyger