The potential impact of work being conducted in genomics, proteomics, and metabolomics upon clinical practice for gynecologists is immense but not yet completely appreciated. This groundbreaking text from international experts examines the newest topics on the perinatal agenda and gives clinicians a  real look into the future via the newest methodologies.

section Section I|1 pages

Pregnancy Complications: Setting the Scene

chapter 1|14 pages

The mother

Adaptation to pregnancy and normal metabolism
ByFrancesca Parisi, Alice Zavatta, Roberta Milazzo, Irene Cetin

chapter 2|5 pages

Maternal and fetal normal and abnormal nutrition

BySarah Louise Killeen, Eilleen C. O'Brien, Fionnuala M. McAuliffe

chapter 3|6 pages

Great obstetrical syndromes

It's all in the placenta
ByMartin Gauster, Gernot Desoye

chapter 4|5 pages

Normal and abnormal fetal growth

ByJavier Caradeux, Eduard Gratacós, Francesc Figueras

chapter 5|5 pages

Preterm labor and birth

ByVincenzo Berghella, Eduardo da Fonseca

chapter 6|6 pages

Gestational diabetes mellitus

BySilvia Vannuccini, Federico Mecacci

chapter 7|6 pages


ByJon Hyett, Liona C. Poon

chapter 8|6 pages

Maternal obesity

ByTahir A. Mahmood, Rohan Chodankar

chapter 9|10 pages

Maternal health Immediate, short-, and long-term complications following pregnancy

ByGil Gutvirtz, Omri Zamstein, Eyal Sheiner

chapter 10|4 pages

The fetus and the neonateImmediate, short-, and long-term impact

ByUmberto Simeoni, Elie Saliba

section Section II|1 pages

Towards Prediction and Prevention

chapter 12|7 pages

Integrated system biology approaches to fetal medicine problems

ByJezid Miranda, Fátima Crispi, Eduard Gratacós

chapter 13|4 pages

Omics and female reproduction

ByGalia Oron

chapter 14|5 pages

Maternal genome and pregnancy outcomes

ByNagendra K. Monangi, Ge Zhang, Mikko Hallman, Kari Teramo, Bo Jacobsson, Louis J. Muglia

chapter 15|5 pages

Placental development and omics

BySylvie Hauguel-de Mouzon, Gernot Desoye, Silvija Cvitic

chapter 16|3 pages

Placental metabolomics in obese pregnancies

ByIrene Cetin, Chiara Novielli, Chiara Mandò

chapter 17|4 pages

Methylome and epigenetic markers

BySkevi Kyriakou, Marios Ioannides, George Koumbaris, Philippos Patsalis

chapter 18|5 pages

Microbiome and pregnancy complications

ByMaria Carmen Collado, Omry Koren

chapter 19|5 pages

Small noncoding RNAs as biomarkers for pregnancy complications

ByLiron Yoffe, Meitar Grad, Avital Luba Polsky, Moshe Hod, Noam Shomron

chapter 20|13 pages

Urine metabolomics and proteomics in prenatal health

ByDaniela Duarte, Maria do Céu Almeida, Pedro Domingues, Ana M. Gil

chapter 21|8 pages

Metabolomics and perinatal complications

ByFlaminia Bardanzellu, Moshe Hod, Vassilios Fanos

chapter 22|6 pages

Metabolomics in normal and pathologic pregnancies

ByAntonio Ragusa, Alessandro Svelato, Sara D'Avino

chapter 23|10 pages

Metabolomics in amniotic fluid

ByAlexandra-Maria Michaelidou, Foteini Tsakoumaki, Maria Fotiou, Charikleia Kyrkou, Apostolos P. Athanasiadis

chapter 24|7 pages

Omics and coagulation disorders in pregnancy

BySara Ornaghi, Michael J. Paidas

chapter 25|16 pages

Omics and perinatal medicinePreeclampsia

ByPiya Chaemsaithong, Liona C. Poon

chapter 26|2 pages

Single nucleotide polymorphisms and pregnancy complications

ByFederica Tarquini, Giuliana Coata, Elena Picchiassi, Gian Carlo Di Renzo

chapter 27|3 pages

Metabolomics and perinatal cardiology

ByRoberta Pintus, Angelica Dessì, Vassilios Fanos

chapter 28|4 pages

Metabolomics and human breast milkA unique and inimitable food for infants

ByFlamina Cesare Marincola, Sara Corbu, Roberta Pintus, Angelica Dessì, Vassilios Fanos

chapter 29|4 pages

Neurodevelopment and placental omics

ByDespina D. Briana, Ariadne Malamitsi-Puchner

chapter 30|7 pages

Early life complications, placental genomics, and risk for neurodevelopmental disorders in offspring

ByPasquale Di Carlo, Giovanna Punzi, Gianluca Ursini

chapter 31|12 pages

Metabolomics and perinatal asphyxia

ByErnesto d'Aloja, Emanuela Locci, Antonio Noto, Matteo Nioi, Giovanni Bazzano, Vassilios Fanos

chapter 32|5 pages

Environment, pregnancy complications, and omics

ByChen Ben David, Ido Solt

chapter 33|5 pages

Sleep and pregnancy complications

ByOrna Sever, Riva Tauman

chapter 34|4 pages

Maternal plasma cell-free DNA screening

Basic science and applications
ByPeter Benn, Howard Cuckle

chapter 35|5 pages

Maternal plasma cell-free DNA screening

Integration into clinical practice
ByHoward Cuckle, Peter Benn

chapter 36|7 pages


ByMelissa Stosic, Jessica L. Giordano, Brynn Levy, Ronald Wapner

chapter 37|9 pages

Whole exome and whole genome sequencing

ByMary E. Norton