ABSTRACT

There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.

section I|2 pages

chapter 1|14 pages

Introduction

ByTeresa Kowalska, Mieczysław Sajewicz, Joseph Sherma

chapter 2|12 pages

Designer Drugs

Legislating for Tomorrow Through the Use of Class Definitions and Pharmacophore Principles
ByGregory W. Endres, Travis J. Worst, Jon E. Sprague

chapter 3|10 pages

Alternative Legislation with Designer Drugs

ByDariusz Zuba

chapter 4|28 pages

Biological Background of Designer Drugs

ByŁukasz Komsta, Katarzyna Wicha-Komsta

chapter 6|8 pages

Ambient Plasma Ionization Techniques in Forensic Analysis

ByPrzemysław Mielczarek, Marek Smoluch

chapter 8|10 pages

Rapid Generation of Metabolites by Electrochemical Method

ByPrzemysław Mielczarek, Marek Smoluch

chapter 9|20 pages

Gas Chromatography–Mass Spectrometry in the Analysis of Designer Drugs

ByBogumiła Byrska, Roman Stanaszek

chapter 10|22 pages

NMR Spectroscopy in the Analysis of Illegal Drugs

ByVlatka Vajs, Iris Djordjević, Ljubodrag Vujisić, Slobodan M. Milosavljević

chapter 11|12 pages

Preparation of Biological Material for Toxicological Analysis

ByMilena Majchrzak, Rafał Celiński

chapter 12|22 pages

Discrimination among Designer Drug Isomers by Chromatographic and Spectrometric Methods

ByPiotr Adamowicz, Dariusz Zuba

section II|2 pages

chapter 13|16 pages

Mass Spectrometric Analysis Applied for the Determination of Synthetic Cannabinoids

ByAkira Namera, Takeshi Saito, Yuji Fujita

chapter 14|26 pages

Cathinone Derivatives and Their Analysis

ByMilena Majchrzak, Rafał Celiński

chapter 15|28 pages

2C Derivatives of Phenylethylamines and Their Analysis

ByBeril Anilanmert, Fatma Çavuş Yonar, Ali Acar Özdemir

chapter 16|24 pages

NBOMe Derivatives of Phenylethylamines and Their Analysis

ByBeril Anilanmert, Fatma Çavuş Yonar, Sena Çağlar Andaç

chapter 17|12 pages

Forensic Analysis of Piperazines

ByChipo Kuleya, Michael D. Cole

chapter 18|28 pages

Chromatographic Analysis of Fentanyl and Its Analogs

ByThomas A. Brettell, Matthew R. Wood

chapter 19|22 pages

Modern Techniques for the Identification of Tryptamines

ByDariusz Zuba

chapter 20|28 pages

Toxicological Analysis of New Opioids

ByKarina Sommerfeld-Klatta, Artur Teżyk, Bogna Geppert

chapter 21|20 pages

Toxicological Analysis of Designer Benzodiazepines

ByArtur Teżyk, Karina Sommerfeld-Klatta, Bogna Geppert

chapter 22|18 pages

Thin-Layer Chromatography in the Analysis of Designer Drugs

ByJoseph Sherma, Teresa Kowalska, Mieczysław Sajewicz