ABSTRACT

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.

chapter 1|13 pages

Neurons-Nerve Cells

ByFang Liu, Tucker A. Patterson, Jingshu Zhang, Merle G. Paule, William Slikker, Cheng Wan

chapter 2|12 pages

Astrocytes

ByCheng Wang, Qi Yin, Shuliang Liu, Xuan Zhang, Fang Liu, Jingshu Zhang, Tucker A. Patterson, Merle G. Paule, William Slikker

chapter 3|18 pages

Oligodendrocytes [Myelin-related Glial Cells in the Central Nervous System (CNS)]

ByShuliang Liu, Merle G. Paule, Fang Liu, Qi Yin, Tucker A. Patterson, William Slikker, Cheng Wang

chapter 4|14 pages

Schwann Cells

ByXuan Zhang, Tucker A. Patterson, Merle G. Paule, Cheng Wang, William Slikker

chapter 5|28 pages

Neuroendocrine Cells

ByZhen He, Sherry A. Ferguson, Tucker A. Patterson, Merle G. Paule

chapter 7|21 pages

Neural Stem Cells and Transplantation

ByMalathi Srivatsan

chapter 8|23 pages

3D in vitro Models for Developmental Neurotoxicity (DNT)

ByLuc Stoppini, Jenny Sandstrom von Tobel, Igor Charvet, Marie-Gabrielle Zurich, Lars Sundstrom, Florianne Monnet-Tschudi

chapter 9|18 pages

Neural Cell Lines (Lineage)

ByQiang Gu

chapter 10|31 pages

Advanced Cell Techniques to Study Developmental Neurobiology and Toxicology

ByThomas Hartung, Helena T. Hogberg, Marcel Leist, David Pamies, Lena Smirnova

chapter 11|20 pages

Anesthesia and Neural Plasticity

ByLaszlo Vutskits

chapter 12|24 pages

Blood-Brain Barrier (BBB)

ByBalabhaskar Prabhakarpandian, Syed Ali, Kapil Pant

chapter 13|20 pages

Neurotrophins and Alzheimer’s Disease

ByJyotshna Kanungo

chapter 14|23 pages

Neurotransmitters and Receptors

ByVesna Jevtovic-Todorovic

chapter 15|17 pages

Neuronal Ion Channels

BySlobodan M. Todorovic

chapter 16|15 pages

Brain Injury-Neuroprotection

ByKoichi Yuki, Mary Ellen McCann, Sulpicio G. Soriano