ABSTRACT

Metabolomics is the scientific study of the chemical processes in a living system, environment and nutrition. It is a relatively new omics science, but the potential applications are wide, including medicine, personalized medicine and intervention studies, food and nutrition, plants, agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field, from masters to postgraduate students, PhDs, postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies, but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather, the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples, computing and exercises.

Key Features:

  • Provides an overview of qualitative /quantitative methods in metabolomics
  • Offers an introduction to the key concepts of metabolomics, including experimental design and technology
  • Covers data handling, processing, analysis, data standards and sharing
  • Contains lots of examples to illustrate the topics
  • Includes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences

chapter 1|13 pages

Overview of Metabolomics

ByOscar Yanes, Reza Salek, Igor Marín de Mas, Marta Cascante

chapter 2|19 pages

Study Design and Preparation

ByPietro Franceschi, Oscar Yanes, Ron Wehrens

chapter 3|38 pages

Measurement Technologies

ByOscar Yanes, Katherine Hollywood, Roland Mumm, Maria Vinaixa, Naomi Rankin, Ron Wehrens, Reza Salek

chapter 4|27 pages

Mass Spectrometry Data Processing

BySteffen Neumann, Oscar Yanes, Roland Mumm, Pietro Franceschi

chapter 5|28 pages

Nuclear Magnetic Resonance Spectroscopy Data Processing

ByMaria Vinaixa, Naomi Rankin, Jeremy Everett, Reza Salek

chapter 6|28 pages

Statistics: The Essentials

ByRon Wehrens, Pietro Franceschi

chapter 7|20 pages

Data Fusion in Metabolomics

ByJohan A. Westerhuis, Frans van der Kloet, Age K. Smilde

chapter 8|24 pages

Genome-Scale Metabolic Networks

ByClément Frainay, Fabien Jourdan

chapter 9|34 pages

Metabolic Flux

ByIgor Marín de Mas, Marta Cascante

chapter 10|18 pages

Data Sharing and Standards

ByReza Salek

chapter 11|6 pages

Conclusion

ByRon Wehrens, Reza Salek