The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. Disease differentiation has impacted diagnosis, treatment and outcome.

part 1|2 pages


chapter 1|28 pages

Bioscience indications for chronic disease management and neuromedical interventions following traumatic brain injury

ByMark J. Ashley, Grace S. Griesbach, David L. Ripley, Matthew J. Ashley

chapter 2|12 pages

The neurobiology of traumatic brain injury

ByThomas C. Glenn, Richard L. Sutton, David A. Hovda

chapter 3|14 pages

Repeat traumatic brain injury models

ByMayumi Prins

chapter 4|10 pages

Neuroplasticity and rehabilitation therapy

ByRobert P. Lehr

chapter 5|10 pages

Environmental enrichment: A preclinical model of neurorehabilitation for traumatic brain injury

ByCorina O. Bondi, Anthony E. Kline

chapter 6|30 pages

Neuroanatomy of basic cognitive function

ByMark J. Ashley, Jessica G. Ashley, Matthew J. Ashley

chapter 8|18 pages

Diet and exercise interventions to promote metabolic homeostasis in TBI pathology

ByFernando Gómez-Pinilla

chapter 11|6 pages

TBI and sensory sensitivity: Translational opportunities

ByTimothy W. Ellis, Jonathan Lifshitz

chapter 12|10 pages

The neuroimaging challenges in hemispherectomy patients

ByZachary Jacokes, Avnish Bhattrai, Carinna Torgerson, Andrew Zywiec, Sumiko Abe, Andrei Irimia, Meng Law, Saman Hazany, John Darrell Van Horn

part 2|2 pages


chapter 13|12 pages

Clinical management of the minimally conscious state

ByYelena G. Bodien, Sabrina R. Taylor, Joseph T. Giacino

chapter 15|10 pages

Clinical management of pituitary dysfunction after traumatic brain injury

ByAdam H. Maghrabi, Brent E. Masel, Randall J. Urban, David L. Ripley

chapter 16|54 pages

Neurotransmitters and pharmacology

ByRonald A. Browning, Richard W. Clough

chapter 17|18 pages

Pituitary dysfunction after traumatic brain injury

ByTiffany Greco

chapter 18|8 pages

Increasing physiologic readiness to improve functional independence following neurotrauma

ByGregory J. O’Shanick, Ryan McQueen

chapter 19|14 pages

Assessment and management of mild traumatic brain injury

ByMark J. Ashley, Matthew J. Ashley

chapter 20|16 pages

Chronic traumatic encephalopathy

ByAnn C. McKee

chapter 21|22 pages

Posttraumatic epilepsy and neurorehabilitation

ByTheresa D. Hernández, Sudha S. Tallavajhula, Kristina T. Legget, Paul M. Levisohn

part 3|2 pages


chapter 22|24 pages

Evaluation of traumatic brain injury following acute rehabilitation

ByMark J. Ashley

chapter 23|12 pages

Neuropsychology following brain injury: A pragmatic approach to outcomes, treatment, and applications

ByJames J. Mahoney, Stephanie D. Bajo, Anthony P. De Marco, Donna K. Broshek

chapter 24|18 pages

Neuropsychological interventions following traumatic brain injury

ByJason W. Krellman, Theodore Tsaousides, Wayne A. Gordon

chapter 25|40 pages

The use of applied behavior analysis in traumatic brain injury rehabilitation

ByCraig S. Persel, Chris H. Persel

chapter 27|26 pages

Remediative approaches for cognitive disorders after TBI

ByMark J. Ashley, Rose Leal, Zenobia Mehta, Jessica G. Ashley, Matthew J. Ashley

chapter 28|28 pages

Principles of cognitive rehabilitation in TBI: An integrative neuroscience approach

ByFofi Constantinidou, Robin D. Thomas

chapter 29|36 pages

Management of residual physical deficits

ByVelda L. Bryan, David W. Harrington, Michael G. Elliott

chapter 30|26 pages

Undertaking vocational rehabilitation in TBI rehabilitation

ByMark J. Ashley, Amy Berryman, Karen Rasavage, Joe Ninomiya

part 4|2 pages

Case management

chapter 32|22 pages

Neurobehavioral consequences of mild traumatic brain injury in military service members and veterans

ByJay M. Uomoto, Sarah M. Wilson, Rhonda M. Williams, Leigh A. Randa

chapter 33|22 pages

Issues in aging following traumatic brain injury

ByGrace S. Griesbach, Mark J. Ashley, Alan Weintraub

chapter 34|20 pages

Children and adolescents: Practical strategies for school participation and transition

ByRoberta Depompei, Janet Siantz Tyler

chapter 35|30 pages

Long-term discharge planning in traumatic brain injury rehabilitation

ByMark J. Ashley, Susan M. Ashley

chapter 36|12 pages

Patients’ rights and responsibilities, health care reform, and telehealth: Ethical considerations

ByThomas R. Kerkhoff, Stephanie L. Hanson