This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

section 1|55 pages

Aspartic Acid Racemization

chapter 1|8 pages

Introduction to Aspartic Acid Racemization

ByChristian Thomas, Sara C. Zapico

chapter 2|10 pages

Aspartic Acid Racemization on Aging

BySara C. Zapico, Christian Thomas, Sofía Tirados Menéndez

chapter 3|15 pages

Aspartic Acid Racemization and Aging in Cartilaginous Tissue

BySarit Sara Sivan, Alice Maroudas, Ellen Wachtel

chapter 5|9 pages

Aspartic Acid Racemization

Applications to Forensic and Archaeological Age Estimation
ByRebecca C. Griffin, Matthew Collins

section 2|71 pages

Advanced Glycation Endproducts

chapter 6|9 pages

Advanced Glycation Endproducts

An Introduction
ByAndreas Simm, Alexander Navarrete Santos

chapter 7|12 pages

Advanced Glycation and Aging

ByAlejandro Gugliucci

chapter 8|20 pages

AGE-RAGE Axis in the Aging and Diabetic Heart

Prime Target for Adjunctive Therapeutic Intervention
ByKaren M. O’Shea, Ann Marie Schmidt, Ravichandran Ramasamy

chapter 9|12 pages

Advanced Glycation Endproducts in Aging Skin

ByParaskevi Gkogkolou, Markus Böhm

chapter 10|10 pages

Advanced Glycation Endproducts and Neurological Diseases

ByTeresita Menini

chapter 11|6 pages

Advanced Glycation Endproducts for Age-at-Death Estimation

ByLuis L. Cabo, Christian Thomas, Sara C. Zapico

section 3|53 pages


chapter 12|10 pages

Introduction to Telomere Biology

ByCelia de Frutos, Pablo Bermejo-Álvarez

chapter 13|9 pages

Role of Telomeres in Aging

ByChristian Thomas, Sara C. Zapico

chapter 14|11 pages

Telomeres and Cardiovascular Diseases

Facts, Controversies and Limitations
ByVicente Andrés, Beatriz Dorado, Ioakim Spyridopoulos

chapter 15|10 pages

Telomeres in Cancer

ByJoão Vinagre, Ana Pestana, Manuel Sobrinho Simões, Paula Soares

section 4|60 pages

Mitochondrial DNA Mutations

chapter 17|8 pages

Introduction to Mitochondria Biology

ByChristian Thomas, Sara C. Zapico

chapter 18|8 pages

Mitochondrial DNA Mutations and Aging

ByRebecca Gordon, Sara C. Zapico

chapter 19|16 pages

Mitochondrial DNA Mutations and Mitochondrial Diseases

ByMaría Elena Gómez-Gómez

chapter 20|10 pages

Reproductive Approaches to Prevent the Transmission of Mitochondrial Diseases

ByMaría Jesús Sánchez-Calabuig, Noelia Fonseca Balvís, Serafín Pérez-Cerezales, Pablo Bermejo-Álvarez

section 5|12 pages


chapter 23|10 pages


Its Role in Aging, Diseases and Biological Age Estimation
ByChristian Thomas, Sara C. Zapico