ABSTRACT

Regulatory agencies worldwide have issued directives or such requirements for air quality standards in embryology laboratories. This practical guide reviews the application of clean room technology or controlled environments specifically suited for Assisted Reproductive Technology (ART) Units. Its comprehensive coverage includes material on airborne particles and volatile organic compounds, including basic concepts, regulation, construction, materials, certification, clinical results in humans, and more.

part |2 pages

Section I: The basics

chapter 1|16 pages

What is a clean room?

chapter 2|14 pages

Clean room technology: An overview of clean room classification standards

ByRaul A. Sadir, Adriano Villarmosa, Luciano Figueiredo

part |2 pages

Section II: Design and construction

chapter 5|10 pages

What is HEPA? How to achieve high efficiency particulate air filtration

ByRaul A. Sadir, Cesar J. Velardez, Raul I. Sadir

chapter 6|10 pages

Volatile organic compounds: Mechanisms of filtration

ByJohn T. Fox

chapter 8|8 pages

Modular clean rooms

ByPatrick J. Traver, George H. Wiker

chapter 9|20 pages

Gases for embryo culture and volatile organic compounds in incubators

ByJayant G. Mehta, Alex C. Varghese

chapter 11|26 pages

Photocatalytic degradation of volatile organic compounds

ByHsin Chu, Yi Hsing Lin, Ting Ke Tseng

part |2 pages

Section III: Operation and monitoring

chapter 12|18 pages

Clean room technology—General guidelines

chapter 14|10 pages

Personnel practices in an IVF clean room facility

ByMartine Nijs, Greta Verheyen

chapter 15|14 pages

Maintaining a clean in vitro fertilization laboratory

BySangita Jindal, Charlene A. Alouf

chapter 16|20 pages

Clean room certification in assisted reproductive technology clinics

ByAlcir Leal dos Santos

chapter 17|12 pages

Testing and monitoring: Volatile organic compounds and microbials

ByBenthe Brauer, Georg Griesinger

part |2 pages

Section IV: Quality management in clean room assisted reproductive units

chapter 18|6 pages

Regulatory requirements for air quality control in reproductive laboratories

BySandro C. Esteves, Fabiola C. Bento

chapter 19|54 pages

Risk management in clean room assisted reproductive units

ByAdrianne K. Pope

chapter 20|12 pages

Troubleshooting aspects in clean room assisted reproductive units

ByRonny Janssens, Johan Guns

part |2 pages

Section V: Clinical outcome and new developments

chapter 23|8 pages

Clean room technology for low resource IVF units

ByAlex C. Varghese, Giles Palmer

chapter 24|8 pages

Sealed culture systems with time-lapse video monitoring

ByKelly Athayde Wirka, Dean E. Morbeck

part |2 pages

Section VI: International experience: Case studies

chapter 25|8 pages

Clean room technology and IVF outcomes: United States

ByTerrence D. Lewis, Aidita N. James, Micah J. Hill, Ryan J. Heitmann

chapter 26|22 pages

Clean room technology and IVF outcomes: Brazil

BySandro C. Esteves, Fabiola C. Bento

chapter 27|6 pages

Clean room technology and IVF outcomes: United Kingdom

ByPaul Knaggs