ABSTRACT

Medicinal Chemistry of Neglected and Tropical Diseases: Advances in the Design and Synthesis of Antimicrobial Agents consolidates and describes modern drug discovery and development approaches currently employed to identify effective chemotherapeutic agents for the treatment of Neglected Tropical Diseases (NTDs) from a medicinal chemistry perspective. Chapters are designed to cater to the needs of medicinal chemists who work with chemotherapeutic developments for NTDs, as well as serve as a guide to budding medicinal chemists who wish to work in this area. It will introduce rational drug design approaches adopted in designing chemotherapeutics and validated targets available for the purpose.

chapter Chapter 2|30 pages

The Application of Fragment-based Approaches to the Discovery of Drugs for Neglected Tropical Diseases

ByChristina Spry, Anthony G. Coyne

chapter Chapter 4|17 pages

Current Inhibitors of Dengue Virus

An Overview
ByJ. Jonathan Harburn, G. Stuart Cockerill

chapter Chapter 5|14 pages

Overview of Drugs used Against Zika Virus

An Overview
BySinem Ilgın, Özlem Atlı Eklioğlu, Begüm Nurpelin Sağlık, Serkan Levent

chapter Chapter 6|15 pages

Chikungunya Virus Infection

A Review of its Control and Treatment
ByD. Velmurugan, K. Manish, D. Gayathri

chapter Chapter 8|19 pages

Prospects of Pre-clinical [6.6.0] Bicyclic Nitrogen Heterocycles in the Treatment of Tuberculosis

ByNeha P. Agre, Mariam S. Degani, Sanjib Bhakta

chapter Chapter 9|19 pages

Progress in Antimalarial Drug Discovery and Development

ByAnna C.C. Aguiar, Wilian A. Cortopassi, Antoniana U. Krettli

chapter Chapter 10|47 pages

Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections

ByTheodora Calogeropoulou, George E. Magoulas, Ina Pöhner, Joanna Panecka-Hofman, Pasquale Linciano, Stefania Ferrari, Nuno Santarem, Ma Dolores Jiménez-Antón, Ana Isabel Olías-Molero, José María Alunda, Anabela Cordeiro da Silva, Rebecca C. Wade, Maria Paola Costi

chapter Chapter 11|18 pages

New Chemical Scaffolds to Selectively Target the Trypanothione Metabolism

ByAndrea Ilari, Gianni Colotti

chapter Chapter 12|31 pages

The Renewal of Interest in Nitroaromatic Drugs

Towards New Anti-Kinetoplastid Agents
ByNicolas Primas, Caroline Ducros, Patrice Vanelle, Pierre Verhaeghe

chapter Chapter 13|29 pages

New Biological Targets for the Treatment of Leishmaniasis

ByFabrizio Carta, Andrea Angeli, Christian D.-T. Nielsen, Claudiu T. Supuran, Agostino Cilibrizzi

chapter Chapter 14|27 pages

Curcumin and Neglected Infectious Diseases

ByFrancesca Mazzacuva, Agostino Cilibrizzi

chapter Chapter 15|19 pages

An Overview of Helminthiasis

Current State and Future Directions
ByLeyla Yurttaș, Betül Kaya Çavușoğlu, Derya Osmaniye, Ulviye Acar Çevik