The aim of this text is to examine the physiological development of the fetus. It allows the reader to study the unique pharmacokinetic and metabolic features of newborns and gives specific examples of drug metabolism in the newborn. The purpose of this book is to enhance the current knowledge of pharmacology of the newborn by observing the embryo and placenta in normal and abnormal development, placental transfer of drugs, metabolic pathways, and metabolism of specific drugs such as theophylline, benzodiazepines, and antibiotics. This is a useful book for those involved in pediatric research, pharmacology, toxicology, experimental therapeutics and biology.

chapter 1|14 pages

Developmental Aspects of Pediatric Pharmacology and Toxicology

ByS. Kacew, S. Lock

chapter 2|20 pages

Fetal and Neonatal Drug Biotransformation

ByMont R. Juchau

chapter 4|26 pages

Pharmacology of Catecholamines

ByArno Zaritsky

chapter 5|42 pages

Antidysrhythmic Drugs in Pediatrics

ByHoward C. Mofenson, Thomas R. Caraccio, Kathleen Mimnagh, Peter Bruzzo

chapter 6|24 pages

Diagnosis and Management of Hypertension in Pediatrics

ByAlbert P. Rocchini

chapter 7|14 pages

Pharmacology and Toxicology of Loop Diuretics in Pediatrics

BySam Kacew

chapter 8|18 pages


BySteven R. Abel, Martin B. Kleiman

chapter 9|12 pages

Developmental Pharmacology of Aminoglycosides and Vancomycin

ByGideon Koren, Julia Klein, Monica Bologa

chapter 10|36 pages

Toxicity of Antineoplastic Chemotherapy in Children

ByTheodore Zwerdling, Steven K. Bergstrom, Stephen D. Smith

chapter 11|12 pages

Barbiturate and Nonbarbiturate Sedative Hypnotic Intoxication

An Overview
ByS. Bertino Joseph, Michael D. Reed

chapter 12|8 pages

The Role of Doxapram in Certain Pediatric Conditions

ByS. Kacew

chapter 13|10 pages

Metabolism and Toxicity of Antiprostaglandin Agents

ByCynthia R. Gelman, Barry H. Rumack

chapter 15|30 pages

Drugs in Gastrointestinal Disorders in Developing Infants

BySam Kacew

chapter 16|12 pages

Iron Poisoning

ByTheodore G. Tong, Banner William