Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies.
Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.

part |83 pages

Part I: Chemistry and Molecular Biology of Iron and Iron-Binding Proteins

part |102 pages

Part II: Iron Accumulation and Metabolism in Humans

chapter 3|24 pages

Iron Balance in Western Societies as Measured by Serum Ferritin

ByBarbara A. Leggett*, June W. Halliday**

chapter 4|30 pages

Hemochromatosis and Other Diseases Associated with Iron Overload

ByJune W. Halliday, Lawrie W. Powell

chapter 5|18 pages

Iron and the Immune System

ByJeremy H. Brock

part |54 pages

Part III: Iron and Oxidative Stress

chapter |22 pages

Chapter 7: Iron and Damage to Biomolecules

ByBarry Halliwell

chapter 8|24 pages

Lipofuscin, Lysosomes, and Iron

ByUlf T. Brunk, Massoud R. Marzabadi, Charles B. Jones

part |70 pages

Part IV: Roles for Iron in Cardiovascular Disease

chapter 9|8 pages

Role of Iron in the Oxidative Modification of LDL

BySampath Parthasarathy

chapter 10|24 pages

The Role of Iron in Myocardial Reperfusion Injury

ByJay L. Zweier

chapter 11|18 pages

Stored Iron as a Risk Factor for Ischemic Heart Disease

ByJerome L. Sullivan

chapter 12|18 pages

Iron and Stroke

ByLance S. Terada, Irene R. Willingham, John E. Repine

part |127 pages

Part V: Roles for Iron in Other Common Diseases

chapter 13|16 pages

Iron and Cancer

ByRichard G. Stevens

chapter 14|16 pages

Brain Iron and Nigrostriatal Dopamine Neurons in Parkinson’s Disease*

ByD. Ben-Shachar, M. B. H. Youdim

chapter 15|30 pages

Proteins of Iron Regulation in the Brain in Alzheimer’s Disease

ByJames R. Connor

chapter 16|24 pages

Iron-Promoted Oxidative Damage in Rheumatic Diseases

ByC. W. Trenam, Paul G. Winyard, Chris J. Morris, David R. Blake

chapter 18|11 pages

Iron Metabolism and Oxygen Radical Injury in Premature Infants

ByJerome L. Sullivan

part |61 pages

Part VI Implications for Prevention and Therapy

chapter 19|18 pages

Preventive Measures for the Maintenance of Low but Adequate Iron Stores

ByRandall B. Lauffer

chapter 20|32 pages

Therapeutic Strategies to Inhibit Iron-Catalyzed Tissue Damage

ByPhilip E. Hallaway, Bo E. Hedlund

chapter 21|10 pages

Epilogue Iron and Oxidative Balance

ByJoe M. McCord