This book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.

section 1|79 pages


chapter 1|16 pages

The Tissue Plasminogen Activator — A Historical Account

ByTage Astrup

chapter 2|28 pages

Plasminogen Activators and Neoplasia

ByKeld Danø, Lars S. Nielsen, Charles Pyke, Geoffrey M. Kellerman

chapter 3|33 pages

t-PA in Fibrin Dissolution and Hemostasis

ByCornells Kluft

section 2|144 pages


chapter 4|18 pages

The Gene for t-PA

ByTor Ny, Monica Ohlsson, Leif Strandberg

chapter 5|22 pages

Structure/Function Relationships of t-PA

ByDick C. Rijken

chapter 6|22 pages

Purification, Assay, and Standardization of t-PA

ByJan H. Verheijen

chapter 7|25 pages

Structure/Function Relationships of Human Plasminogen and Plasmin

ByFrancis J. Castellino

chapter 8|17 pages

Fibrinogen and its Specific Sites for Modulation of t-PA Induced Fibrinolysis

ByWillem Nieuwenhuizen

chapter 9|22 pages

Inhibitors of Plasminogen Activators

ByEgbert K. O. Kruithof

chapter 10|14 pages

Control of t-PA-Mediated Fibrinolysis

ByMats Rånby, Anders Brändström