The Process of New Drug Discovery and Development | Charles G. Smith,

Book

The Process of New Drug Discovery and Development

ABSTRACT

The Process of New Drug Discovery and Development, Second Edition presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new addition updates the scientific advances in new drug discovery and development for areas

TABLE OF CONTENTS

chapter 1|6 pages

Introduction

chapter 2|8 pages

Overview of the Current Process of New Drug Discovery and Development

chapter 3|40 pages

Integrated Drug Product Development — From Lead Candidate Selection to Life-Cycle Management

chapter 4|24 pages

The Impact of Combinatorial Chemistry on Drug Discovery

chapter 5|24 pages

High-Throughput Screening: Enabling and Influencing the Process of Drug Discovery

chapter 6|32 pages

Pharmacological and Pharmaceutical Profiling: New Trends

chapter 7|14 pages

Cell-Based Analysis of Drug Response Using Moving Optical Gradient Fields

chapter 8|12 pages

Patient-Derived Primary Cells in High-Throughput Differential Antitumor Screens: Let the Patients Be the Guide

chapter 9|26 pages

The Evolving Role of the Caco-2 Cell Model to Estimate Intestinal Absorption Potential and Elucidate Transport Mechanisms

chapter 10|12 pages

The Promise of Metabonomics in Drug Discovery

chapter 11|26 pages

Pharmacogenetics and Pharmacogenomics in Drug Development and Regulatory Decision-Making: Report of the First FDA–PWG– PhRMA–DruSafe Workshop

chapter 12|18 pages

Drugs from Molecular Targets for CNS and Neurodegenerative Diseases

chapter 13|48 pages

Safety Pharmacology: Past, Present, and Future

chapter 14|14 pages

Nonclinical Drug Safety Assessment

chapter 15|10 pages

Preclinical Genotoxicity Testing — Past, Present, and Future

chapter 16|14 pages

The Need for Animals in Biomedical Research

chapter 17|6 pages

Defining the Actual Research Approach to the New Drug Substance

chapter 18|42 pages

Pharmacokinetics –– Pharmacodynamics in New Drug Development

chapter 19|24 pages

Pharmaceutics and Compounding Issues in New Drug Development and Marketing

chapter 20|6 pages

Late Stage and Process Development Activities

chapter 21|12 pages

Contract Research Organizations: Role and Function in New Drug Development

chapter 22|26 pages

The Front Lines of Clinical Research: The Industry

chapter 23|14 pages

Horizons for Cancer Chemotherapy (and Nonchemotherapy)

chapter 24|14 pages

Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome: Clinical Testing Challenges

chapter 25|8 pages

Common Technical Document: The Changing Face of the New Drug Application

chapter 26|2 pages

Electronic Publishing

chapter 27|6 pages

The Important Role of Pharmacists in a Complex Risk-Management System: Managing the Risks from Medical Product Use by Focusing on Patient Education, Monitoring, and Adverse Event Reporting

chapter 28|32 pages

Liability, Litigation, and Lessons in New Drug Development

chapter 29|12 pages

Problems in the Nondrug Marketplace

chapter 30|14 pages

Patents and New Product Development in the Pharmaceutical and Biotechnology Industries

chapter 31|18 pages

The Pharmaceutical Revolution: Drug Discovery and Development

chapter 32|20 pages

The Discovery of Rituxan

chapter 33|18 pages

Funding the Birth of a Drug: Lessons from the Sell Side

chapter 34|14 pages

Innovations for the Drug Development Pathway: What Is Needed Now

chapter 35|42 pages

Managing R&D Uncertainty and Maximizing the Commercial Potential of Pharmaceutical Compounds Using the Dynamic Modeling Framework