Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

section Section I|1 pages

Assessing Cognitive Aging

chapter 1|18 pages

Changes in Cognitive Function in Human Aging

ByElizabeth L. Glisky

chapter 2|18 pages

Successful vs. Unsuccessful Aging in the Rhesus Monkey

ByMark B. Moss, Tara L. Moore, Stephen P. Schettler, Ronald Killiany, Douglas Rosene

chapter 3|22 pages

Neuropsychology of Cognitive Aging in Rodents

ByJoshua S. Rodefer, Mark G. Baxter

section Section II|1 pages

Quantifying Aging-Related Changes in the Brain

chapter 4|34 pages

Design-Based Stereology in Brain Aging Research

ByChristoph Schmitz, Patrick R. Hof

chapter 6|32 pages

Neurogenesis in the Adult and Aging Brain

ByDavid R. Riddle, Robin J. Lichtenwalner

chapter 7|28 pages

Expression Profile Analysis of Brain Aging

ByStephen D. Ginsberg

section Section III|1 pages

Assessing Functional Changes in the Aging Nervous System

chapter 8|24 pages

Subtle Alterations in Glutamatergic Synapses Underlie the Aging-Related Decline in Hippocampal Function

ByLei Shi, Michelle Adams, Judy K. Brunso-Bechtold

chapter 9|16 pages

Assessment of Second Messenger Function in the Hippocampus of Aged Rats with Cognitive Impairment

ByMichelle M. Nicolle, Hai-Yan Zhang, Jennifer L. Bizon

chapter 10|22 pages

Neurophysiology of Old Neurons and Synapses

ByAshok Kumar, Thomas C. Foster

chapter 11|26 pages

Imaging Cognition in the Aging Human Brain

ByTrey Hedden

section Section IV|1 pages

Mechanisms Contributing to Brain Aging

chapter 12|26 pages

Regulation of Cerebrovascular Aging

ByWilliam E. Sonntag, Delrae M. Eckman, Jeremy Ingraham, David R. Riddle

chapter 13|18 pages

Stress and Glucocorticoid Contributions to Normal and Pathological Aging

ByKi A. Goosens, Robert M. Sapolsky

chapter 14|30 pages

Altered Calcium Homeostasis in Old Neurons

ByEmil C. Toescu

chapter 15|22 pages

Oxidative Stress and the Aging Brain: From Theory to Prevention

ByCarmelina Gemma, Jennifer Vila, Adam Bachstetter, Paula C. Bickford