ABSTRACT

Reviewing current studies and previously unpublished research from leading laboratories around the world, Unravelling Lipid Metabolism With Microarrays demonstrates the use of microarrays and transcriptomic approaches to clarify the biological function of lipids. It provides an extensive overview of statistical approaches to microarray data, as well as discussions on how microarrays can be used to understand the role of lipids in the initiation or prevention of disorders such as cancer, diabetes, and obesity. Of particular note is a chapter by the only group known to study the effect of lipids on transcriptomics in multiple brain regions.

chapter 1|34 pages

Statistical Design and Data Analysis for Microarray Experiments

ByDarlene R. Goldstein, Mauro Delorenzi

chapter 5|16 pages

Neurological Effects of Dietary n-3 Fatty Acids in Rat Brain

ByTibor Farkas, Klára Kitajka, Gwendolyn Barceló-Coblijn, László G. Puskás

chapter 6|24 pages

Anterior and Posterior Cerebral Gene Expression in a Rat Model of Reduced Brain Docosahexaenoic Acid During Development

ByJudy B. Gaines, Nancy E. J. Berman, Susan E. Carlson

chapter 7|24 pages

A Genomic Approach to Studying Leptin Signaling in a Hypothalamic Cell Line

ByWiweka Kaszubska, Paul Hessler, Paul E. Kroeger

chapter 9|22 pages

Microarray Analysis of Lipid Metabolism in Drug Abuse, Neurological and Psychiatric Disorders

ByE. Lehrmann, C.-T. Lee, J. Chen, W. J. Freed, K. G. Becker

chapter 10|12 pages

Microarray Analyses of SREBP-1 Target Genes

ByNaoya Yahagi, Hitoshi Shimano

chapter 11|15 pages

Understanding the Coordinated Effects of PPARs on Lipid Metabolism Using Microarrays

BySander Kersten, Pascal Escher, Sherrie Tafuri, Walter Wahli

chapter 12|30 pages

Microarray Analysis of Changes Induced by Peroxisome Proliferator-activated Receptor α Agonists in the Expression of Genes Involved in Lipid Metabolism

ByKazuto Yamazaki, Taro Hihara, Hideki Yoshitomi, Junro Kuromitsu, Isao Tanaka

chapter 13|25 pages

How Dietary Long-Chain Fatty Acids Induce Gene Signals Involved in Carcinogenesis

ByPascale Anderle, Pierre Farmer, Alvin Berger, Matthew A. Roberts

chapter 14|19 pages

Omega-3 Polyunsaturated Fatty Acid Against Colon Cancer: DNA Microarray Analysis of Gene–Nutrient Interactions

ByBhagavathi A. Narayanan, Narayanan K. Narayanan, Bandaru S. Reddy

chapter 15|15 pages

Ellagic Acid Modulates Lipid Metabolism in Prostate Cancer: Gene–Nutrient Interactions

ByBhagavathi A. Narayanan, Narayanan K. Narayanan, Otto Geoffroy, Daniel W. Nixon

chapter 16|24 pages

Changes of Gene Expression in INS-1 cells: The implication of palmitate in lipotoxicity

ByJianzhong Xiao, Per Bendix Jeppesen, Abudula Reziwanggu, Mogens Kruhøffer, Torben Ørntoft, Kjeld Hermansen

chapter 18|18 pages

Metabonomics as a Tool for Understanding Lipid Metabolism

ByDavid J. Grainger, David E. Mosedale, Elaine Holmes, Jeremy K. Nicholson

chapter 19|9 pages

Zebrafish Model of Lipid Metabolism for Drug Discovery

ByAmy L. Rubinstein, Shiu-Ying Ho, Steven A. Farber