ABSTRACT

Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation o

chapter 1|14 pages

Overview of Time-to-Event Endpoint Methodology

ByKarl E. Peace

chapter 2|56 pages

Design (and Monitoring) of Clinical Trials with Time-to-Event Endpoints

ByMichael W. Sill, Larry Rubinstein

chapter 3|22 pages

Overview of Time-to-Event Parametric Methods

ByKarl E. Peace, Kao-Tai Tsai

chapter 4|16 pages

Overview of Semiparametric Inferential Methods for Time-to-Event Endpoints

ByJianwen Cai, Donglin Zeng

chapter 7|18 pages

An Efficient Alternative to the Cox Model for Small Time-to-Event Trials

ByDevan V. Mehrotra, Arthur J. Roth

chapter 8|32 pages

Estimation and Testing for Change in Hazard for Time-to-Event Endpoints

ByRafia Bhore, Mohammad Huque

chapter 9|14 pages

Overview of Descriptive and Graphical Methods for Time-to-Event Data

ByMichael O’Connell and Bob Treder

chapter 10|28 pages

Design and Analysis of Analgesic Trials

ByAkiko Okamoto, Julia Wang, Surya Mohanty

chapter 11|24 pages

Design and Analysis of Analgesic Trials with Paired Time-to-Event Endpoints

ByZhu Wang, Hon Keung Tony Ng

chapter 12|12 pages

Time-to-Event Endpoint Methods in Antibiotic Trials

ByKarl E. Peace

chapter 13|28 pages

Design and Analysis of Cardiovascular Prevention Trials

ByMichelle McNabb, Andreas Sashegyi

chapter 14|16 pages

Design and Analysis of Antiviral Trials

ByAnthony C. Segreti, Lynn P. Dix

chapter 15|22 pages

Cure Rate Models with Applications to Melanoma and Prostate Cancer Data

ByMing-Hui Chen, Sungduk Kim

chapter 17|34 pages

Design, Summarization, Analysis, and Interpretation of Cancer Prevention Trials

ByMatthew C. Somerville, Jennifer B. Shannon, Timothy H. Wilson

chapter 19|14 pages

Selecting Optimal Treatments Based on Predictive Factors

ByEric C. Polley, Mark J. van der Laan

chapter 20|28 pages

Application of Time-to-Event Methods in the Assessment of Safety in Clinical Trials

ByKelly L. Moore, Mark J. van der Laan

chapter 21|68 pages

Design and Analysis of Chronic Carcinogenicity Studies of Pharmaceuticals in Rodents*

ByMohammad Atiar Rahman, Karl K. Lin

chapter 22|34 pages

Design and Analysis of Time-to-Tumor Response in Animal Studies: A Bayesian Perspective

BySteve Thomson, Karl K. Lin