Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of

chapter 1|16 pages

The Impact o f B lood Substitutes on B lood Banking W orldwide

ByMassac husetts General Hospital, and Harvard Medical School Boston Massachusetts Internati Geneva Switzerland

chapter 2|12 pages

Potential Use of Red Blood Cell Substitutes Within the Military

ByU.S. Navy Blood Program Washington

chapter 3|8 pages

B lood Substitutes: Unique Regulatory A spects

ByFood and Drug Administration Bethesda, Maryland

chapter 4|32 pages

O xygen Transport, O xygen Carriers, and the Transfusion Trigger

ByUniversi La Jolla California

chapter 5|10 pages

M icrocirculatory C onsequences o f B lood Substitution with H em oglobin Solutions

ByUniversi La Jolla California

chapter 6|40 pages

Efficacy of Perflubron-Based Emulsion as a Temporary Oxygen Carrier

ByAlliance Pharmaceutical Corp., San Diego, California

chapter 8|24 pages

Immunological Alterations Following Hemorrhagic Shock: Considerations for Resuscitation with Blood Substitutes

ByBrown Univ and Rhode Island Hospital Providence Rhode Island

chapter 9|30 pages

Renal Effects of Hemoglobin-Based Blood Substitutes

ByEvans Memorial Department of Clinical Research, and Boston Medical Center, Boston, Massachusetts

chapter 10|16 pages

Interactions of Hemoglobin with the Central Nervous System

ByS. Scott Panter, Raymond F. Regan

chapter 11|28 pages

Interactions Between Hemoglobin and Bacterial Endotoxin In Vitro and In Vivo

ByJack Levin, Robert I. Roth

chapter 12|24 pages

Encapsulation of Hemoglobin in Liposomes

ByReuven Rabinovici, William T. Phillips, Giora Z. Feuerstein, Alan S. Rudolph

chapter 13|22 pages

The Use of Blood Substitutes in Tumor Therapy

ByRobert E. Meyer, Mark W. Dewhirst

chapter 16|18 pages

Production, Characterization, and Clinical Evaluation of Hemolink™, an Oxidized Raffinose Cross-Linked Hemoglobin-Based Blood Substitute

ByJ. Gordon Adamson, Bonnie J. Bonaventura, Song S. Er, Richard T. Jones, Susan F. Langlois, I. David MacDonald

chapter 18|20 pages

The Clinical Development of Human Polymerized Hemoglobin

BySteven A. Gould, Lakshman R. Sehgal, Hansa L. Seghal, Gerald S. Moss

chapter 20|28 pages

Medical and Therapeutic Applications of Perfluorocarbon-Based Products

ByStephen F. Flaim

chapter 21|10 pages

Future Perspectives of Red Blood Cell Substitutes

ByThomas Ming Swi Chang