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High Throughput Screening
DOI link for High Throughput Screening
High Throughput Screening book
The Discovery of Bioactive Substances
High Throughput Screening
DOI link for High Throughput Screening
High Throughput Screening book
The Discovery of Bioactive Substances
Edited ByJohn P. Devlin
Edition 1st Edition
First Published 1997
eBook Published 21 April 2014
Pub. Location Boca Raton
Imprint CRC Press
Pages 704
eBook ISBN 9780429175152
Subjects Bioscience
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Devlin, J.P. (Ed.). (1997). High Throughput Screening: The Discovery of Bioactive Substances (1st ed.). CRC Press. https://doi.org/10.1201/9781482269802
ABSTRACT
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high
TABLE OF CONTENTS
part |144 pages
Natural Products as a Discovery Resource
chapter 1|46 pages
Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds
ByJohn P. Devlin
part II|127 pages
Compound Sourcing: Chemically Generated Screening Libraires
chapter 6|12 pages
Rapidly Expanding Molecular Diversity: Libraries from Libraries
ByJohn S. Kiely, Barbara Dörner, John M. Ostresh, Colette Dooley, Richard A. Houghten
chapter 7|24 pages
Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS
ByJack J. Baldwin, Ian Henderson
chapter 8|17 pages
Parallel Organic Synthesis Using Parke-Davis' Diversomer® Method
BySheila Hobbs DeWitt, Anthony W. Czarnik
chapter 9|13 pages
Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods
ByAdnan M. M. Mjalli, Barry E. Toyonaga
chapter 10|20 pages
CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction of Phenazines
ByFerenc Darvas, László Kovács
chapter 11|8 pages
Design of a Diverse Screening Library
ByDavid E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, John R. Peterson
chapter 12|11 pages
Automating Combinatorial Chemistry: Challenges and Pitfalls
ByJill H. Hardin, Frank R. Smietana
chapter 13|9 pages
Combi-chem High Throughput Screening for Leads Optimization
ByRichard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, Stephen Felder
part III|182 pages
Assay Technologies and Detection Methods
chapter 17|12 pages
FlashPlate Technology
ByBeverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, Simon Ng
chapter 18|15 pages
Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors
ByMaureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, Wai Lee T. Wong
chapter 19|16 pages
Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery
ByAlfred J. Kolb, Jocelyn W. Burke, Gerard Mathis
chapter 21|12 pages
Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats
ByJanet M. Kolb, Greg Yamanaka, Susan P. Manly
chapter 22|11 pages
Fluorescence Polarization
ByJ. Richard Sportsman, Sandra K. Lee, Hara Dilley, Robert Bukar
chapter 24|13 pages
Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction
ByD.K.H. Lee, E. T. Wilkinson, S. Cheifetz, S.A. De Grandis
chapter 25|16 pages
High-Performance Microphysiometry in Drug Discovery
ByM. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D.H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, Jana Williams
chapter 26|12 pages
Bio-analytical Applications of BIAcore, an Optical Biosensor
ByFrancois Legay, Albientz Patrick, Rüdiger Ridder
part IV|91 pages
Automation and Robotics
chapter 30|9 pages
Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program
ByElizabeth A. Kunysz, Melissa Lukes, Douglas W. Bonhaus
chapter 31|16 pages
Factors for the Successful Integration of Assays, Equipment, Robotics, and Software
ByDejan Bojanic, Wilma W. Keighley, Mike J. Russell, Terry P. Wood
chapter 32|15 pages
Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?
ByRichard K. Brown, Andree Proulx
part V|75 pages
Data Retrieval, Handling and Integration
part IV|46 pages
Laboratory Design and Management
chapter 40|16 pages
Establishing an HTS Program in a Start-Up Biotechnology Company
ByMichael D. Boisclair, James Schultz, Dan Maloney
