This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,

chapter 1|78 pages

The Solid Support

chapter 2|24 pages

Strategy in Solid-Phase Peptide Synthesis

ByT. Scott Yokum, George Barany

chapter 3|26 pages

Amino Acids: Alpha-Amino Protecting Groups

ByJohn D. Wade

chapter 4|68 pages

Side-Chain Protecting Groups

ByAmanda L. Doherty-Kirby, Gilles A. Lajoie

chapter 5|78 pages

Solid Supports for the Synthesis of Peptides and Small Molecules

ByChristopher Blackburn

chapter 6|56 pages

Coupling Methods: Solid-Phase Formation of Amide and Ester Bonds

ByBonds Fernando Albericio, Steven A. Kates

chapter 7|34 pages

Homodetic Cyclic Peptides

ByPaolo Rovero

chapter 8|12 pages

Disulfide Formation in Synthetic Peptides and Proteins: The State of the Art

ByDavid Andreu, Ernesto Nicolas

chapter 9|42 pages

Solid-Phase Convergent Approaches to the Synthesis of Native Peptides and Proteins

ByPaul Lloyd- Williams and Ernest Giralt

chapter 10|56 pages

Preparation of Glyco-, Phospho-, and Sulfopeptides

ByCarlos Garda-Echeverria

chapter 11|54 pages

II. Oligonucleotide Synthesis

ByLaurent Bellon, Francine Wincott

chapter 12|20 pages

Synthesis of Oligonucleotide-Peptide Conjugates and Nucleopeptides

ByRamon Eritja

chapter 13|30 pages

The Chemistry of Peptide Nucleic Acids

ByMichael Egholm, Ralph A. Casale

chapter 14|38 pages

Solid-Phase Synthesis of Oligosaccharides

ByJacques Y. Roberge

chapter 15|32 pages

Solid-Phase Synthesis of Heterocyclic Compounds from Amino Acids and Linear Peptides

ByAdel Nejzi, John M. Ostresh, Richard A. Houghten

chapter 17|30 pages


ByScott B. Daniels

chapter 18|16 pages

The Purification of Synthetic Peptides

ByJohn S. McMurray

chapter 19|40 pages

Analysis of Synthetic Peptides

ByNicholas P. Ambulos, Jr., Lisa Bibbs, Lynda F Bonewald, Steven A. Kates, Ashok Khatri, Katalin Folkl Medzihradszky, and Susan T. Weintraub

chapter 20|28 pages

The Chromatographic Analysis of Combinatorial Arrays: Parallel HPLC and HPLC-MS

ByVern de Biasi and Andrew Organ