ABSTRACT

One of the most intriguing discoveries in molecular biology in the last decade is the existence of an evolutionary conserved and essential system, consisting of molecular chaperones and folding catalysts, which promotes the folding of the proteins in the cell. This text summarizes our current knowledge of the cellular roles, the regulation and the

part I|2 pages

INTRODUCTION

chapter 1|8 pages

ASSISTED PROTEIN FOLDING

ByB. Bukau, F. X. Schmid, J. Buchner

part III|2 pages

CELLULAR FUNCTIONS

chapter 7|25 pages

GENETIC DISSECTION OF THE Hsp70 CHAPERONE SYSTEM OF YEAST

ByE. Craig, W. Yan, P. James

chapter 8|16 pages

FUNCTIONS IN DEVELOPMENT

ByM. Morange

chapter 9|30 pages

EARLY EVENTS IN THE SYNTHESIS AND MATURATION OF POLYPEPTIDES

ByW. J. Welch, D. K. Eggers, W. J. Hansen, H. Nagata

chapter 10|34 pages

PROTEIN TRANSPORT INTO AND FOLDING WITHIN THE ENDOPLASMIC RETICULUM

ByI. G. Haas, R. Zimmermann

chapter 12|19 pages

PROTEIN IMPORT INTO AND FOLDING WITHIN CHLOROPLASTS

ByE. Muckel, J. Soll

chapter 13|15 pages

PROTEIN FOLDING IN THE PERIPLASM OF ESCHERICHIA COLI

ByD. Missiakas, C. Dartigalongue, S. Raina

chapter 16|19 pages

ROLE OF CHAPERONES IN UNCOATING OF CLATHRIN COATED VESICLES

ByE. Eisenberg, L. Greene

chapter 17|37 pages

THE ROLE OF HSP104 IN STRESS TOLERANCE AND PRION MAINTENANCE

ByS. Lindquist, E. C. Schirmer

chapter 18|25 pages

CHAPERONES AND CHARONINS: PROTEIN UNFOLDING ENZYMES AND PROTEOLYSIS

ByM. R. Maurizi, S. Wickner, S. Gottesman

part IV|2 pages

MECHANISMS

chapter 19|31 pages

SPONTANEOUS VERSUS ASSISTED PROTEIN FOLDING

ByR. Jaenicke, R. Seckler

chapter 21|33 pages

PEPTIDYL-PROLYL CIS/TRANS ISOMERASES

ByG. Fischer, F. X. Schmid

chapter 22|33 pages

THE ATPase CYCLE OF THE GroE MOLECULAR CHAPERONES

ByN. A. Ranson, A. R. Clarke

chapter 23|35 pages

THE RELATIONSHIP BETWEEN CHAPERONIN STRUCTURE AND FUNCTION

ByS. G. Burston, H. R. Saibil

chapter 25|38 pages

STRUCTURE AND MECHANISM OF HSP70 PROTEINS

ByJ.-H.Ha , E.R.Johnson , D.B.McKay , M.C.Sousa , S.Takeda and S.M.Wilbanks

chapter 27|29 pages

MECHANISMS OF ATP-INDEPENDENT VS. ATP-DEPENDENT CHAPERONES

ByS. Bose, M. Ehrnsperger, J. Buchner