Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c

chapter 1|34 pages

Multiplicity Problems in Clinical Trials: A Regulatory Perspective

ByMohammad Huque and Joachim Ro¨hmel

chapter 2|64 pages

Multiple Testing Methodology

ByAlex Dmitrienko, Frank Bretz, Peter H. Westfall, James Troendle, Brian L. Wiens, Ajit C. Tamhane, Jason C. Hsu

chapter 3|32 pages

Multiple Testing in Dose-Response Problems

chapter 4|34 pages

Analysis of Multiple Endpoints in Clinical Trials

ByAjit C. Tamhane, Alex Dmitrienko

chapter 5|28 pages

Gatekeeping Procedures in Clinical Trials

ByAlex Dmitrienko, Ajit C. Tamhane

chapter 6|46 pages

Adaptive Designs and Confirmatory Hypothesis Testing

ByWilli Maurer, Michael Branson, Martin Posch