ABSTRACT

Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat

chapter 1|30 pages

▪ Evolution, Regulation, and Disruption of Homeostasis and Its Role in Carcinogenesis

ByALEXANDER R. A. ANDERSON, DAVID BASANTA, PHILIP GERLEE, AND KATARZYNA A. REJNIAK

chapter 2|14 pages

▪ Cancer Cell: Linking Oncogenic Signaling to Molecular Structure

ByJEREMY E. PURVIS, ANDREW J. SHIH, YINGTING LIU, RAVI RADHAKRISHNAN

chapter 3|22 pages

▪ Has Cancer Sculpted the Genome? Modeling Linkage and the Role of Tetraploidy in Neoplastic Progression

ByCARLO C. MALEY, WALTER LEWIS, BRIAN J. REID

chapter 5|24 pages

▪ A Stochastic Multiscale Model Framework for Colonic Stem Cell Homeostasis

ByLARRY W. JEAN AND E. GEORG LUEBECK

chapter 6|24 pages

▪ Multiscale Modeling of Colonic Crypts and Early Colorectal Cancer

ByALEXANDER G. FLETCHER, GARY R. MIRAMS, PHILIP J. MURRAY, ALEX WALTER, JUN-WON KANG, KWANG-HYUN CHO, PHILIP K. MAINI,

chapter 7|22 pages

▪ The Physical Microenvironment in Somatic Evolution of Cancer

ByROBERT A. GATENBY

chapter 8|16 pages

▪ Multiscale Modeling of Cell Motion in Three- Dimensional Environments

ByDEWI HARJANTO, MUHAMMAD H. ZAMAN

chapter 9|20 pages

▪ Simulating Cancer Growth with Agent-Based Models S. DEISBOECK

ByZHIHUI WANG, VERONIKA BORDAS, JONATHAN SAGOTSKY, THOMAS

chapter 10|20 pages

▪ Diffusional Instability as a Mechanism of Tumor Invasion

ByHERMANN B. FRIEBOES, JOHN LOWENGRUB, VITTORIO CRISTINI

chapter 11|24 pages

▪ Continuum Models of Mesenchymal Cell Migration and Sprouting Angiogenesis

ByMICHAEL BERGDORF, FLORIAN MILDE, PETROS KOUMOUTSAKOS

chapter 12|16 pages

▪ Do Tumor Invasion Strategies Follow Basic Physical Laws?

ByCATERINA GUIOT, PIER POALO DELSANTO, AND ANTONIO SALVADOR GLIOZZI

chapter 13|56 pages

▪ Multiscale Mathematical Modeling of Vascular Tumor Growth: An Exercise in Transatlantic Cooperation

ByMARK A.J. CHAPLAIN, PAUL MACKLIN, STEPHEN MCDOUGALL, ALEXANDER R.A. ANDERSON, VITTORIO CRISTINI, AND JOHN LOWENGRUB

chapter 14|30 pages

▪ A Multiscale Simulation Framework for Modeling Solid Tumor Growth with an Explicit Vessel Network

BySVEN HIRSCH, BRYN LLOYD, DOMINIK SZCZERBA, GABOR SZÉKELY

chapter 15|20 pages

▪ Building Stochastic Models for Cancer Growth and Treatment

ByNATALIA L. KOMAROVA

chapter 16|26 pages

▪ Bridging from Multiscale Modeling to Practical Clinical Applications in the Study of Human Gliomas

ByGARGI CHAKRABORTY, RITA SODT, SUSAN MASSEY, STANLEY GU, RUSSELL ROCKNE, ELLSWORTH C. ALVORD, JR., AND KRISTIN R. SWANSON

chapter 17|22 pages

▪ Personalization of Reaction-Diffusion Tumor Growth Models in MR Images: Application to Brain Gliomas Characterization and Radiotherapy Planning

ByENDER KONUKOGLU, OLIVIER CLATZ, HERVÉ DELINGETTE, AND NICHOLAS AYACHE