ABSTRACT

Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable and non-implantable devices, rehabilitation, psychotherapy, and behavioral interventions. Unlike pharmacological treatments, these have no specific requirements for approval. Consequently, they can be widely proposed in clinical pra

chapter 1|8 pages

Blinding in Nonpharmacological Randomized Controlled Trials

ByIsabelle Boutron, Philippe Ravaud

chapter 2|16 pages

Placebo in Nonpharmacological Randomized Trials*

ByAsbjørn Hróbjartsson, Franklin G. Miller

chapter 3|16 pages

Complexity of the Intervention

ByPatricia Yudkin, Rafael Perera, Paul Glasziou

chapter 4|12 pages

Learning Curves

ByJonathan A. Cook, Craig R. Ramsay

chapter 5|12 pages

Clustering Effects in RCTs of Nonpharmacological Interventions

ByJonathan A. Cook

chapter 6|14 pages

Assessment of Harm

ByPanagiotis N. Papanikolaou and John P.A. Ioannidis

chapter 7|12 pages

External Validity and Applicability of Nonpharmacological Trials

ByIsabelle Boutron, Philippe Ravaud

chapter 8|10 pages

Assessing Nonpharmacological Interventions in Cluster Randomized Trials

ByBruno Giraudeau, Philippe Ravaud

chapter 9|10 pages

Expertise-Based Trials

ByJonathan A. Cook

chapter 10|18 pages

Pragmatic Trials and Nonpharmacological Evaluation

ByMerrick Zwarenstein

chapter 11|12 pages

Preference Trials

ByArthur Kang’ombe, Helen Tilbrook, and David Torgerson

chapter 13|16 pages

Methodological and Reporting Considerations for Systematic Reviews of Nonpharmacological Interventions

ByAlexander Tsertsvadze, Larissa Shamseer, David Moher

chapter 15|14 pages

Reporting Guidelines for Nonpharmacological Trials

ByIsabelle Boutron, Philippe Ravaud

chapter 16|16 pages

Assessing Cardiothoracic Surgery: Practical Examples

ByTom Treasure, Martin Utley

chapter 17|12 pages

Assessing Obstetrics and Gynecology: Practical Examples

ByVincenzo Berghella, Jorge E. Tolosa

chapter 18|14 pages

Assessing Lower Limb Arthroplasty: Practical Examples

ByDavid Biau, Remy Nizard

chapter 19|14 pages

Assessing Radiation Therapy: Practical Examples

ByHidefumi Aoyama

chapter 20|10 pages

Assessing Electroconvulsive Therapy: Practical Examples

ByKeith G. Rasmussen

chapter 22|14 pages

Assessing Orthosis: Practical Examples

ByKatherine Sanchez, Claire Jourdan, François Rannou, and Serge Poiraudeau

chapter 23|16 pages

Assessing Rehabilitation: Practical Examples

ByNadine Elizabeth Foster

chapter 24|14 pages

Assessing Psychotherapy: Practical Examples

ByPaula P. Schnurr

chapter 25|18 pages

Assessing Psychosocial Interventions for Mental Health: Practical Examples

ByGraham Thornicroft, Michele Tansella

chapter 27|10 pages

Assessing Hypnotherapy: Practical Examples

ByIsabelle Marc