This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson's disease, Alzheimer's disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induce

chapter 1|10 pages


ByDavid R. Brown

chapter 2|22 pages

A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease

ByBrian J. Tabner, Susan Moore, Jennifer Mayes, David Allsop

chapter 3|48 pages

Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration

ByEwa Gralka, Daniela Valensin, Maurizio Remelli, Henryk Kozlowski

chapter 4|56 pages

Mammalian Metallothioneins

ByDuncan E. K. Sutherland, Martin J. Stillman

chapter 5|32 pages

Copper Transporting P-Type ATPases in the Brain

BySharon La Fontaine, James Camakaris, Julian Mercer

chapter 6|52 pages

Role of the Amyloid Precursor Protein and Copper in Alzheimer’s Disease

ByLoredana Spoerri, Kevin J. Barnham, Gerd Multhaup, Roberto Cappai

chapter 7|28 pages

Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer’s Disease

BySilvia Bolognin, Paolo Zatta

chapter 8|46 pages

Prion Diseases, Metals and Antioxidants

ByPaul Davies, David R. Brown

chapter 9|32 pages

Emerging Role for Copper-Bound α-Synuclein in Parkinson’s Disease Etiology

ByHeather R. Lucas, Jennifer C. Lee