Genetic Predisposition to Cancer, 2Ed | Ros Eng, Douglas Easton, Bruce

Book

Genetic Predisposition to Cancer, 2Ed

ABSTRACT

Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehe

TABLE OF CONTENTS

part |2 pages

PART 1: BASIC PRINCIPLES

chapter 1|8 pages

Genetic predisposition to cancer: an introduction

chapter 2|10 pages

Biological basis of cancer predisposition

chapter 3|20 pages

From families to chromosomes: genetic linkage and association studies for finding cancer- predisposition genes

chapter 4|7 pages

From chromosomes to genes: how to isolate cancer-predisposition genes

chapter 5|13 pages

Screening for mutations in cancer-predisposition genes

part |2 pages

PART 2: INHERITED CANCER SYNDROMES

chapter 6|10 pages

Retinoblastoma: the paradigm for a genetically inherited cancer syndrome

chapter 7|24 pages

Neurofibromatosis types 1 and 2

chapter |8 pages

8a Multiple endocrine neoplasia type 1

chapter |14 pages

8b Multiple endocrine neoplasia type 2

chapter 9|13 pages

Wilms tumour and other childhood renal tumours

chapter 10|9 pages

Genetic susceptibility to renal cell carcinoma

chapter 11|14 pages

The Li–Fraumeni syndrome and the role of TP53 mutations in predisposition to cancer

chapter 12|12 pages

Cowden syndrome

part |2 pages

PART 3: CHROMOSOME FRAGILITY SYNDROMES AND THE GORLIN SYNDROME

chapter 13|11 pages

Clinical, cellular and mutational variations in ataxia telangiectasia

chapter 14|13 pages

Fanconi anaemia

chapter 15|21 pages

The Gorlin (nevoid basal cell carcinoma) syndrome

chapter 16|19 pages

Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer

part |2 pages

PART 4: THE COMMON CANCERS

chapter 17|13 pages

Genetics and the common cancers

chapter 18|8 pages

Familial breast cancer

chapter 19|21 pages

The BRCA1 and BRCA2 genes

chapter 20|9 pages

Screening for breast cancer in high-risk populations

chapter 21|10 pages

Risk-reducing mastectomy

chapter 22|7 pages

The role of chemoprevention in breast cancer

chapter 23|12 pages

Familial ovarian cancer: genetics and management

chapter 24|19 pages

Familial colon cancer syndromes and their genetics

chapter 25|8 pages

Screening and management of familial colon cancer

chapter 26|13 pages

Familial prostate cancer and its management

chapter 27|8 pages

Familial melanoma and its management

chapter 28|8 pages

Familial predisposition to lung cancer

chapter 29|21 pages

Genetic susceptibility to carcinoma of the head and neck, stomach, and pancreas

part |2 pages

PART 5: PSYCHOSOCIAL, ETHICAL AND ORGANISATIONAL ISSUES

chapter 30|13 pages

The cancer family clinic

chapter 31|10 pages

Psychological issues in cancer genetics

chapter 32|12 pages

The ethics of testing for cancer-predisposition genes