This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal

chapter 1|12 pages

Periprosthetic Osteolysis Around Total Hips and Total Knees

ByWilliam H. Harris

chapter 2|40 pages

Fixation of Implants

ByCalin S. Moucha, Robert M. Urban, Thomas M. Turner, Joshua J. Jacobs, Dale R. Sumner

chapter 3|10 pages

Fixation of Implants with Bone Cement

ByHans Georg Willert and Georg Ko¨ster

chapter 4|26 pages

Total Hip Replacement: Incidence of Osteolysis and Clinical Presentation

ByRajiv K. Sethi, Sanjeev Agarwal, Harry E. Rubash

chapter 5|16 pages

Total Knee Arthroplasty: Incidence of Osteolysis and Clinical Presentation

ByJeffrey Wiley, Daniel M. Estok, II

chapter 6|18 pages

Histopathology of Periprosthetic Tissues

ByStuart B. Goodman, Victor Fornasier

chapter 7|22 pages

Properties of Biomaterials Used in Joint Replacements

ByTimothy M. Wright, Robert F. Closkey Jr

chapter 8|26 pages

Wear of Joint Replacements

ByJohn Fisher

chapter 9|40 pages

Human Motion and Its Relevance to Wear and Failure in Total Knee Arthroplasty

ByMarkus A. Wimmer, Thomas P. Andriacchi

chapter 10|44 pages

Corrosion of Metallic Implants

ByNadim James Hallab, Joshua J. Jacobs, Jeremy L. Gilbert

chapter 11|26 pages

Inflammation and the Role of Macrophages in the Foreign Body Reaction

ByJames M. Anderson

chapter 12|46 pages

Cytokines and Mediators in Physiologic and Pathologic Bone Resorption

ByDavid R. Haynes, Tania N. Crotti

chapter 13|18 pages

Wear Debris Mediated Osteolysis: An Overview

ByArun Shanbhag

chapter 14|30 pages

Role of the Immune Response in Implant Loosening

ByPaul H. Wooley

chapter 15|24 pages

Stress-Related Bone Resorption

ByJ. D. Bobyn, M. Tanzer, A. H. Glassman

chapter 16|14 pages

Pressure- and Motion-Induced Factors in Implant Loosening

ByPer Aspenberg

chapter 17|16 pages

Role of Endotoxin in Implant Loosening

ByFabian von Knoch, Harry E. Rubash, Arun Shanbhag, Steven R. Goldring, and David R. Cho

chapter 18|24 pages

Signal Transduction and Gene Regulation in Cell–Material Interactions

ByElizabeth A. Fritz, Kenneth A. Roebuck, Tibor T. Giant

chapter 19|26 pages

In Vitro and In Vivo Models for Understanding Osteolysis

ByBrian L. Puskas, Mark J. Neavyn, Arun Shanbhag

chapter 20|18 pages

Surgical Techniques: Modern Cementing Techniques

ByCraig J. Della Valle, Richard A. Berger

chapter 21|44 pages

Treating Hip and Pelvic Osteolysis

ByEric L. Martin, Stephen Burnett, Wayne Paprosky

chapter 22|18 pages

Managing Knee Osteolysis

ByJohn Lyon, Aaron Rosenberg

chapter 23|34 pages

Advances in Metals

ByCheryl R. Blanchard, Dana J. Medlin, Ravi Shetty

chapter 24|26 pages

Advances in Polyethylene

ByAnuj Bellare, Lisa A. Pruitt

chapter 25|24 pages

Improving UHMWPE Using Electron Beam Irradiation

ByOrhun K. Muratoglu, William H. Harris

chapter 26|22 pages

Alternate Bearing Materials: Metal-on-Metal

ByMauricio Silva, Thomas P. Schmalzried

chapter 27|22 pages

Alternate Bearing Materials: Ceramic-on-Ceramic

ByJustin P. Hawes, Jonathan P. Garino

chapter 28|40 pages

Tissue Engineering Alternatives to Joint Replacement

ByB. Kinner, M. Spector

chapter 29|28 pages

Enhancing Cementless Fixation

ByDale R. Sumner, Amarjit S. Virdi, Robert M. Leven, Kevin E. Healy

chapter 30|24 pages

Genome Sciences in Clinical Orthopaedics

ByArun Shanbhag, Grant E. Garrigues, Adam M. Kaufman, Harry E. Rubash