Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding

chapter 1|4 pages


ByAkira Tsuda, Peter Gehr

chapter 2|16 pages


ByAkira Tsuda, Frank S. Henry

chapter 3|26 pages

Interaction with the Lung Surface

ByPeter Gehr, Akira Tsuda

chapter 4|26 pages

Role of the Biomolecule Corona in Nanoparticle Fate and Behavior

ByIseult Lynch

chapter 5|12 pages

Interaction with Alveolar Lining Fluid

ByVincent Castranova, Dale W. Porter, Robert R. Mercer

chapter 6|22 pages

Interaction with Lung Macrophages

ByBarry Weinberger, Patrick J. Sinko, Jeffrey D. Laskin, Debra L. Laskin

chapter 7|26 pages

Interactions with Alveolar Epithelium

ByFarnoosh Fazlollahi, Yong Ho Kim, Arnold Sipos, Zea Borok, Kwang-Jin Kim, and Edward D. Crandall

chapter 8|14 pages

Mechanistic Aspects of Cellular Uptake

ByLennart Treuel, Xiue Jiang, Gerd Ulrich Nienhaus

chapter 9|22 pages

Cellular Uptake and Intracellular Trafficking

ByBarbara Rothen-Rutishauser, Dagmar A. Kuhn, Dimitri Vanhecke, Fabian Herzog, Alke Petri-Fink, and Martin J.D. Clift

chapter 10|14 pages

Translocation across the Air–Blood Tissue Barrier

ByFabian Blank, Christophe von Garnier, Peter Gehr, and Barbara Rothen-Rutishauser

chapter 11|14 pages

The Pulmonary Lymphatic System

ByAkira Tsuda

chapter 12|14 pages

Translocation and Accumulation in the Body

ByWolfgang G. Kreyling

chapter 13|14 pages

Practical Considerations for Drug Delivery to the Respiratory Tract

ByJohn S. Patton

chapter 14|14 pages

Drug and Gene Delivery in the Lungs

BySatoshi Uchida, Keiji Itaka, Kazunori Kataoka

chapter 15|12 pages

Bio-Nanocapsules: Novel Drug Delivery

ByShun’ichi Kuroda

chapter 16|16 pages

Physicochemical, Colloidal, and Transport Properties

ByHeinrich Hofmann, Lionel Maurizi, Marie-Gabrielle Beuzelin, Usawadee Sakulkhu, Vianney Bernau

chapter 17|28 pages

Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore

ByJoel M. Cohen, Philip Demokritou

chapter 18|28 pages

Potential for Nose-to-Brain Delivery of Drugs

ByLisbeth Illum

chapter 19|18 pages

The Developing Lungs

ByAkira Tsuda, Frank S. Henry

chapter 20|24 pages


ByDominique Balharry, Eva Gubbins, Helinor Johnston, Ali Kermanizadeh, Vicki Stone

chapter 21|4 pages


ByPeter Gehr, Akira Tsuda