This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

section I|40 pages

Introduction to Aging

chapter 1|20 pages

A Synopsis on Aging

ByJoão Pinto da Costa

chapter 2|18 pages

Understanding Aging after Darwin

ByMichael A. Singer

section II|166 pages

Aging Hypothesis

chapter 3|30 pages

Evolutionary Theories of Aging: A Systemic and Mechanistic Perspective

ByQuentin Vanhaelen

chapter 4|18 pages

The Indispensable Soma Hypothesis in Aging

ByMarios Kyriazis

chapter 5|26 pages

Programmed Aging Paradigm and Aging of Perennial Neurons

ByGiacinto Libertini

chapter 6|18 pages

The Genetic Program of Aging

ByXiufang Wang, Huanling Zhang, Libo Su, Zhanjun Lv

chapter 7|26 pages

The Origins of Aging

Multicellularity, Speciation, and Ecosystems
ByMichael A. Singer

chapter 8|14 pages

Human Culture

Urbanization and Human Aging
ByMichael A. Singer

chapter 9|32 pages

Aging Epigenetics

Accumulation of Errors and More
ByVasily V. Ashapkin, Lyudmila I. Kutueva, Boris F. Vanyushin

section III|174 pages

Diseases Associated with Aging and Treatment

chapter 10|22 pages

The Premature Aging Characteristics of RecQ Helicases

ByChrist Ordookhanian, Taylor N. Dennis, J. Jefferson P. Perry

chapter 11|6 pages

Cockayne Syndrome and the Aging Process

ByMaría de la Luz Arenas-Sordo

chapter 12|10 pages


The Price for Longevity
ByKarel Smetana, Barbora Dvořánková, Lukáš Lacina, Pavol Szabo, Betr Brož, Aleksi Šedo

chapter 13|12 pages

Nodular Thyroid Disease with Aging

ByEnke Baldini, Salvatore Sorrenti, Antonio Catania, Francesco Tartaglia, Daniele Pironi, Massimo Vergine, Massimo Monti, Angelo Filippini, Salvatore Ulisse

chapter 14|12 pages

HIV and Aging

A Multifaceted Relationship
ByEdward J. Wing

chapter 15|34 pages

Maturation, Barrier Function, Aging, and Breakdown of the Blood–Brain Barrier

ByElizabeth de Lange, Ágnes Bajza, Péter Imre, Attila Csorba, László Dénes, Franciska Erdő

chapter 16|30 pages

Senescent Cells as Drivers of Age-Related Diseases

ByCielo Mae D. Marquez, Michael C. Velarde

chapter 17|16 pages

Osteoimmunology in Aging

ByLia Ginaldi, Daniela Di Silvestre, Maria Maddalena Sirufo, Massimo De Martinis

chapter 18|6 pages

Manipulating Aging to Treat Age-Related Disease

ByV. Mallikarjun, J. Swift

chapter 19|24 pages

Therapeutic Options to Enhance Poststroke Recovery in Aged Humans

ByAurel Popa-Wagner, Dumbrava Danut, Roxana Surugiu, Eugen Petcu, Daniela-Gabriela Glavan, Denissa-Greta Olaru, Raluca Sandu Elena

section IV|106 pages

Mechanisms of Aging

chapter 21|28 pages

Mitochondrial Oxidative Stress in Aging and Healthspan

ByDao-Fu Dai

chapter 22|14 pages

Immunology of Aging and Cancer Development

ByT. Fulop, J. M. Witkowski, G. Dupuis, A. Le Page, A. Larbi, G. Pawelec

chapter 23|18 pages

Oxidation of Ion Channels in the Aging Process

ByFederico Sesti

chapter 24|20 pages

Lipid Raft Alteration and Functional Impairment in Aged Neuronal Membranes

ByJulie Colin, Lynn Gregory-Pauron, Frances T. Yen, Thierry Oster, Catherine Malaplate-Armand

chapter 25|12 pages

Autophagy: The Way to Death or Immortality? Activators and Inhibitors of Autophagy as Possible Modulators of the Aging Process

ByGalina V. Morgunova, Alexander A. Klebanov, Alexander N. Khokhlov

section V|28 pages

Treatments in Aging

chapter 26|10 pages


Grounds and Determents
BySreeja Lakshmi, Preetham Elumalai

section VI|60 pages

Healthy and Successful Aging

chapter 28|8 pages

Social Structure and Healthy Aging

Case Studies *
ByJong In Kim, Gukbin Kim

chapter 29|18 pages

Successful Aging

Role of Cognition, Personality, and Whole-Person Wellness
ByPeter Martin, Leonard W. Poon, Kyuho Lee, Yousun Baek, Jennifer A. Margrett

chapter 30|16 pages

Physical Activity in Prevention of Glucocorticoid Myopathy and Sarcopenia in Aging

ByTeet Seene, Priit Kaasik

chapter 31|16 pages

Reductionism versus Systems Thinking in Aging Research

ByMarios Kyriazis

section VII|22 pages

Anti-Aging Drugs

chapter 32|20 pages

Anti-Aging Drug Discovery in Experimental Gerontological Studies

From Organism to Cell and Back
ByAlexander N. Khokhlov, Alexander A. Klebanov, Galina V. Morgunova

section VIII|18 pages

Aging in Caenorhabditis elegans

section IX|20 pages

Hibernation and Aging

chapter 34|18 pages

Hibernation and Aging

Molecular Mechanisms of Mammalian Hypometabolism and Its Links to Longevity
ByCheng-Wei Wu, Kenneth B. Storey

section X|18 pages

Mathematical Modeling of Aging

chapter 35|16 pages

The Role of Mathematical Modeling in Understanding Aging

ByMark Mc Auley, Amy Morgan, Kathleen Mooney