The objective of this book is to illustrate in specific detail how cardiovascular mechanics stands as a common pillar supporting such different clinical successes as drugs for high blood pressure, prosthetic heart valves and coronary artery bypass grafting, among others. This information is conveyed through a comprehensive treatment of the overarching principles and theories that are behind mechanobiological processes, aortic and arterial mechanics, atherosclerosis, blood and microcirculation, hear valve mechanics, as well as medical devices and drugs.

  • Examines all major theoretical and practical aspects of mechanical forces related to the cardiovascular system.
  • Discusses a unique coverage of mechanical changes related to an aging cardiovascular system.
  • Provides an overview of experimental methods in cardiovascular mechanics.
  • Written by world-class researchers from Canada, the US and EU.
  • Extensive references are provided at the end of each chapter to enhance further study.

Michel R. Labrosse is the founder of the Cardiovascular Mechanics Laboratory at the University of Ottawa, where he is a full professor within the Department of Mechanical Engineering. He has been an active researcher in academia along with being heavily associated with the University of Ottawa Heart Institute. He has authored or co-authored over 90 refereed communications, and supervised or co-supervised over 40 graduate students and post-docs.

chapter 1|17 pages

Cardiovascular System:

Anatomy and Physiology
ByC. A. Gibbons Kroeker

chapter 2|44 pages

Cell and Extracellular Matrix Interactions in a Dynamic Biomechanical Environment:

The Aortic Valve as an Illustrative Example
ByA. Y. L. Lam, C. A. Simmons

chapter 3|27 pages

Blood Flow Mechanics

ByM. Fenech, L. Haya

chapter 4|38 pages

Experimental Methods in Cardiovascular Mechanics

ByM. R. Labrosse, L. Kadem

chapter 5|54 pages

Computational Methods in Cardiovascular Mechanics

ByF. Auricchio, M. Conti, A. Lefieux, S. Morganti, A. Reali, G. Rozza, A. Veneziani

chapter 6|44 pages

Aortic and Arterial Mechanics

ByS. Avril

chapter 7|25 pages

Atherosclerosis and Mechanical Forces

ByM. Kozakova, C. Palombo

chapter 8|26 pages

Red Blood Cell and Platelet Mechanics

ByS. Gekle, M. Bender

chapter 9|40 pages

Aortic Valve Mechanics

ByJ. Dallard, M. Boodhwani, M. R. Labrosse

chapter 10|13 pages

Mitral Valve Mechanics

ByA. Tran, T. G. Mesana, V. Chan

chapter 12|33 pages

Mechanical Effects of Cardiovascular Drugs and Devices

ByK. May-Newman