ABSTRACT

Pioneers in the field, the editors have assembled an excellent team of contributors with extensive experience of threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. Comprehensive and up-to-date, this reference provides fully up-to-date information on currently available methods of drug delivery, as well as illustrations of drug delivery methods with seventy-five color and seventy-five black and white photos throughout the book. With this impressive presentation of the most up-to-date methods and applications, as well as a range of photographs illustrating their implementation, this guide is an excellent resource for cardiologists, pharmacologists, cardiac surgeons, and trainees.

chapter 1|6 pages

The purpose of site-specific therapy

ByCezar Staniloae, Richard Gallo, Juan J Badimon

chapter 3|18 pages

Catheter-based and stent-based treatment for coronary artery disease

ByJames Spratt, Edoardo Camenzind

chapter 4|10 pages

The ClearWay™ microporous balloon catheter

ByGeoffrey Moodie, Steve Grantz, Paul Martakos

chapter 6|8 pages

The Remedy™ PTCA dilatation infusion catheter

ByWendy Naimark, James Barry

chapter 7|7 pages

The Infiltrator™ angioplasty balloon catheter

ByAlexander Popov, Herbert Radisch, Peter Barath

chapter 8|4 pages

The Infiltrator™ local drug delivery catheter

ByPeter Sinnaeve, Stefan Janssens

chapter 9|17 pages

The needle catheter

chapter 10|17 pages

Stent-mediated local drug delivery

ByYanming Huang, Ivan K De Scheerder

chapter 11|9 pages

Silicon carbide-coated stents

ByBernd Heublein†

chapter 12|9 pages

The Carbostent: a Carbofilm™-coatedstent

chapter 13|8 pages

The PC-coated BiodivYsio™ stent

ByAndrew Lewis, Julian Gunn

chapter 14|8 pages

PTFE-covered stents

ByRichard Heuser

chapter 15|16 pages

Overview of drug delivery coatings

chapter 17|14 pages

Direct stent coating: an alternative for polymers?

ByKoen J Salu, Johan M Bosmans, Hidde Bult, Chris J Vrints

chapter 18|10 pages

Radioactive stents

ByChristoph Hehrlein

part 19|2 pages

Overview of potential drugs to inhibit in-stent restenosis

chapter 20|5 pages

Direct antithrombins

ByVincenzo Toschi

chapter 21|4 pages

Tissue factor inhibitors

ByMaddalena Lettino, Vincenzo Toschi, Juan Jose Badimon

chapter 22|19 pages

Nitric oxide-related interventions and restenosis

ByHidde Bult, Koen Salu and Guido RY De Meyer

chapter 23|14 pages

Vitamin E and its multiple properties: anti, pro, and non-oxidative activities

ByXianShun Liu and Ivan K De Scheerder

chapter 24|7 pages

The dexamethasone eluting stent

chapter 25|16 pages

Antiinflammatory approaches to restenosis

ByIvan K De Scheerder, Yanming Huang

chapter 30|6 pages

Site-specific delivery of cytostatic agents

ByMartin Oberhoff, Christian Herdeg, Karl R Karsch

chapter 31|9 pages

Catheter-based delivery of NOS gene

ByStefan Janssens

chapter 32|9 pages

Carbon-coated stents: diamond-like stent coatings

ByIvan K De Scheerder, Yanming Huang

chapter 35|5 pages

Glycoprotein (GP) GIIb/IIIa receptor antagonist eluting stents

ByNeil Swanson, Anthony Gershlick

part 36|2 pages

Activated protein C eluting stents

chapter 39|7 pages

Rapamycin eluting stents

ByRobert L Wilensky, Bruce D Klugherz

chapter 41|9 pages

Local delivery of paclitaxel as a stent coating

ByAlan W Heldman

chapter 43|5 pages

Vascular endothelial growth factor (VEGF) eluting stents

ByNeil Swanson, Anthony Gershlick

chapter 45|5 pages

Stent-based gene delivery

ByBruce D Klugherz, Robert J Levy, Robert L Wilensky

chapter 46|10 pages

Catheter-based local heparin delivery

ByAaron V Kaplan, Antonio L Bartorelli

chapter 47|7 pages

Local delivery of low molecular weight heparins

ByR Stefan Kiesz, M Marius Rozek, Jack L Martin

chapter 48|18 pages

Local delivery of steroids before coronary stent implantation

ByBernhard Reimers, Antonio Colombo

chapter 49|7 pages

Clinical studies with the Carbostent

ByAntonio L Bartorelli, Daniela Trabattoni

chapter 50|3 pages

Gold-coated stents

chapter 51|9 pages

Heparin-coated stent trials

BySjoerd H Hofma, Patrick W Serruys, Willem J van der Giessen

chapter 53|16 pages

Dexamethasone: mode of action, preclinical, and clinical studies

ByIvan K De Scheerder, Xiaoshun Liu, Yanming Huang, Eric Verbeken

chapter 56|6 pages

The FIM trial: sirolimus eluting stents

chapter 57|5 pages

Tacrolimus eluting stents

ByEberhard Grube

chapter 58|9 pages

Everolimus eluting stents

ByEberhard Grube, Lutz Buellesfeld

chapter 59|10 pages

The Quanam drug eluting stent and the SCORE trial

ByEberhard Grube

chapter 60|13 pages

The Boston Scientific paclitaxel eluting stent: TAXUS I and II

ByEberhard Grube

chapter 62|13 pages

Intrapericardial drug delivery for prevention of restenosis

ByDongming Hou, Keith L March

chapter 64|12 pages

Drug eluting stents: a critical perspective*