ABSTRACT

Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source sp

chapter 1|16 pages

Introduction to Genetics

ByEva Halapi, Hakon Hakonarson

chapter 2|16 pages

Genetic Epidemiology of Reduced Lung Function

ByCleo C. van Diemen, H. Marike Boezen

chapter 3|22 pages

Gene–Environment Interaction in Asthma

ByGerard H. Koppelman, Dirkje S. Postma

chapter 4|20 pages

Epistatic Interaction, Age, and Gender Effects

ByMichael Kabesch

chapter 5|30 pages

Microarray Techniques and Data in Asthma/Chronic Obstructuve Pulmonary Disease

ByThomas J. Mariani, Marco F. Ramoni

chapter 6|22 pages

Mouse Models for Asthma and Mouse Asthma Genetics

ByBenoit Piavaux, Antoon J. M. van Oosterout

chapter 7|32 pages

Generation of Genetically Manipuated Mouse Lines for the Study of Asthma

ByStephen L. Tilley, Irving C. Allen, Beverly H. Koller

chapter 8|20 pages

Comparative Genomics of Asthma

ByIoannis M. Stylianou, Jaspal Singh, David A. Schwartz

chapter 9|20 pages

Proteomic Techniques for Asthma and Chronic Obstructive Pulmonary Disease Research

ByMegan S. Lim, Kojo S. J. Elenitoba-Johnson

chapter 10|12 pages

Linkage to Asthma and Its Intermediate Phenotypes

ByTimothy D. Howard and Juan C. Celedo´n

chapter 11|12 pages

Linkage Analysis of Spirometric Phenotypes and Chronic Obstructive Pulmonary Disease

ByDawn L. Demeo, Craig P. Hersh, Edwin K. Silverman

chapter 12|16 pages

Fine Mapping and Whole Genome Association Studies in Asthma and Chronic Obstructive Pulmonary Disease

ByMiriam F. Moffatt, William O. C. Cookson

chapter 13|34 pages

Association Studies in Asthma

ByIngrid A. Laing and Peter N. Le Soue¨f

chapter 14|26 pages

Association Studies in Chronic Obstructive Pulmonary Disease

ByTakeo Ishii, Andrew J. Sandford

chapter 15|18 pages

b2-Adrenergic Receptor Polymorphisms and Asthmatic Phenotypes

ByStephen B. Liggett, Ian P. Hall

chapter 16|16 pages

Interleukin-13

ByDonata Vercelli

chapter 17|24 pages

CD14 and Toll-Like Receptors

ByStefano Guerra, Fernando D. Martinez

chapter 18|42 pages

Pharmacogenetics

ByKelan Tantisira, Eugene Bleecker