ABSTRACT

Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer preventio

chapter 1|26 pages

The Molecular Pathogenesis and Pathophysiology of Prostate Cancer

ByWilliam G. Nelson, Angelo M. De Marzo

chapter 2|12 pages

Targeted Therapies for Cancer: Definitions and Attributes

ByEdward A. Sausville

chapter 3|20 pages

Novel Biomarkers for Disease Diagnosis, Prognosis, and Prediction

ByJames V. Tricoli

chapter 4|16 pages

The Endothelin Pathway and its Modulation in Prostate Cancer

ByAntonio Jimeno, Michael Carducci

chapter 6|12 pages

Immunologic Approaches to Prostate Cancer

ByLawrence Fong, Eric J. Small

chapter 7|24 pages

Gene Therapy and Novel Clinical Trial Design

ByHenry T. Tsai, Jonathan W. Simons

chapter 8|16 pages

Angiogenesis Inhibitors in Prostate Cancer

ByWilliam D. Figg, Michael C. Cox, Tania Alachalabi, William L. Dahut

chapter 9|20 pages

What Antisense Oligonucleotides Have Promise in Prostate Cancer

ByKim N. Chi, Martin E. Gleave

chapter 10|16 pages

Novel Approaches to Androgen Receptor Blockade

ByIngo K. Mellinghoff

chapter 11|16 pages

Can Post-Transcription Modifiers Change the Course of Prostate Cancer?

ByDavid Z. Qian, Roberto Pili

chapter 12|14 pages

Telomere Targeting Agents

ByAngelika M. Burger, Lloyd R. Kelland

chapter 13|14 pages

Expanding the Role of EGFR Inhibitors in Prostate Cancer

BySrikala S. Sridhar, Malcolm J. Moore

chapter 14|14 pages

Bone-Directed Therapy in Prostate Cancer: Rationale and Novel Approaches

ByColby L. Eaton, Kate D. Linton, Freddie C. Hamdy

chapter 15|8 pages

Inhibiting the Proteasome in Advanced Prostate Cancer

ByRobert Dreicer

chapter 16|12 pages

Hsp90: A Target for Prostate Cancer Therapy

ByDavid B. Solit, Howard I. Scher, Neal Rosen

chapter 17|24 pages

Vitamin D Analogs and Their Role in Prostate Cancer

ByTomasz M. Beer, Anne Myrthue

chapter 18|10 pages

Other Novel Therapies

ByArif Hussain, Richard Schraeder

chapter 19|24 pages

Molecular Imaging, Clinical Trial Design, and the Development of Emerging Therapies for Metastatic Prostate Cancer

ByMichael J. Morris, Neeta Pandit-Taksar, Chaitanya Divgi, Steven Larson, Howard I. Scher