ABSTRACT

Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and can

chapter 1|26 pages

The Myelodysplastic Syndromes: History and Classification

ByDavid P. Steensma, John M. Bennett

chapter 2|22 pages

Epidemiology of the Myelodysplastic Syndromes

ByTerry J. Hamblin

chapter 3|38 pages

The Cytogenetics and Molecular Biology of the Myelodysplastic Syndromes

ByHarold J. Olney, Michelle M. Le Beau

chapter 4|20 pages

Genomic Approaches in MDS

ByAndrea Pellagatti

chapter 5|20 pages

The Role of Apoptosis in MDS

ByYatato Yoshida

chapter 6|26 pages

The Role of Mitochondria in MDS

ByNorbert Gattermann

chapter 7|20 pages

Defects in Iron Metabolism and Iron Overload in MDS

ByLuca Malcovati

chapter 8|22 pages

Therapy-Related Myelodysplastic Syndrome and Myeloid Leukemia

ByLucy A. Godley, Richard A. Larson

chapter 9|32 pages

Diagnosis of Myelodysplastic Syndromes: Criteria and Challenges

ByAttilio Orazi, James W. Vardiman

chapter |8 pages

Color Inserts

chapter 11|20 pages

Diagnostic and Prognostic Utility of Flow Cytometry in MDS

ByDenise A. Wells, Michael R. Loken

chapter 12|18 pages

Molecular Pathogenesis of the 5q− Syndrome

ByJacqueline Boultwood, James S. Wainscoat

chapter 13|26 pages

Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/ Myeloproliferative Overlap Syndromes

ByPhuong L. Nguyen, Curtis A. Hanson

chapter 14|36 pages

MDS in Children

ByHenrik Hasle, Charlotte M. Niemeyer

chapter 15|46 pages

Prognostic Factors in the Assessment of Patients with Myelodysplastic Syndromes

ByAristoteles Giagounidis, Carlo Aul, Ulrich Germing

chapter 16|20 pages

Therapeutic Strategies: The Approach to Care of Patients with MDS, and Criteria for Treatment Response

ByPierre Fenaux, Lionel Ades, Claude Gardin

chapter 17|24 pages

Management of Cytopenias in MDS

ByLuca Malcovati, David T. Bowen and Eva Hellstro¨m-Lindberg

chapter 18|20 pages

Immune Dysregulation and the Role for Immunotherapy in Myelodysplastic Syndrome (MDS)

ByKebede Hussein, David P. Steensma

chapter 19|28 pages

Lenalidomide Therapy in MDS

ByRami Komrokji, Aristoteles Giagounidis, Alan F. List

chapter 21|30 pages

Intensive Chemotherapy and Stem Cell Transplantation in Myelodysplastic Syndromes

ByGuillermo F. Sanz and Theo de Witte