ABSTRACT

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e

chapter 1|9 pages

Principles of developmental toxicology revisited

ByRonald D. Hood

chapter 2|35 pages

Experimental approaches to evaluate mechanisms of developmental toxicity

ByElaine M. Faustman, Julia M. Gohlke, Rafael A. Ponce, Tom A. Lewandowski, Marguerite R. Seeley, Stephen G. Whittaker, William C. Griffith

chapter 3|15 pages

Experimental approaches to evaluate mechanisms of reproductive toxicity

ByJackye Peretz, Zelieann R. Craig, Stacey Bunting, Jodi A. Flaws

chapter 4|16 pages

Maternally-mediated effects on development

ByRonald D. Hood, John M. Rogers

chapter 5|17 pages

Paternally-mediated effects on development

ByBarbara F. Hales, Bernard Robaire

chapter 6|46 pages

Comparative gestational milestones in vertebrate development

ByJohn M. DeSesso

chapter 7|45 pages

Developmental toxicity testing—Methodology

ByRochelle W. Tyl, Melissa C. Marr

chapter 8|45 pages

Reproductive toxicity testing—Methodology

ByRobert M. Parker

chapter 9|73 pages

Significance, reliability, and interpretation of developmental and reproductive toxicity study findings

ByDonald G. Stump, Mark D. Nemec, George A. Parker, Prägati Sawhney Coder, Eddie D. Sloter, Bennett J. Varsho

chapter 10|44 pages

Nonclinical juvenile toxicity testing

ByMelissa J. Beck, Eric L. Padgett, George A. Parker, Gwendalyn M. Maginnis, Jonathan D. Toot, Bennett J. Varsho, Julie S. Varsho

chapter 11|42 pages

Neurobehavioral testing for developmental toxicity

ByDevon L. Graham, Tori L. Schaefer, Charles V. Vorhees

chapter 12|21 pages

The U.S. EPA Endocrine Disruptor Screening Program: The Tier 1 Screening Battery

BySusan C. Laws, Brandy W. Riffle, Tammy E. Stoker, Jerome M. Goldman, Vickie Wilson, L. Earl Gray, Jr., and Ralph L. Cooper

chapter 13|20 pages

In vitro screening methods for developmental toxicology

ByRobert G. Ellis-Hutchings, Esther de Jong, Aldert H. Piersma, and Edward W. Carney

chapter 14|16 pages

Approaches for evaluation of mode of action

ByBarbara D. Abbott, Mitchell B. Rosen, Andrew M. Watkins, Carmen R. Wood

chapter 15|19 pages

Functional genomics and proteomics in developmental and reproductive toxicology

ByRobert M. Cabrera, Bogdan J. Wlodarczyk, Richard H. Finnell

chapter 16|15 pages

Nonhuman primates as preclinical models for developmental and reproductive toxicity evaluation

ByGerhard F. Weinbauer, Antje Fuchs, C. Marc Luetjens, Michael Niehaus, Marc O. Niehoff, Elvira Vogelwedde

chapter 17|12 pages

Developmental and reproductive safety assessment of biopharmaceuticals

ByChristopher J. Bowman, Pauline L. Martin

chapter 18|18 pages

Developmental immunotoxicity testing

ByLeigh Ann Burns-Naas

chapter 19|9 pages

Developmental and reproductive safety testing of vaccines

ByMeredith S. Rocca

chapter 20|24 pages

Use of toxicokinetics in developmental and reproductive toxicology

ByPatrick J. Wier

chapter 21|21 pages

Understanding statistics in developmental and reproductive toxicology

ByTom Vidmar, Les Freshwater, Roger Collins

chapter 23|14 pages

Predictive modeling and computational toxicology

ByNicole C. Kleinstreuer, Thomas B. Knudsen

chapter 24|10 pages

Critical evaluation of current developmental toxicity testing strategies—A case of babies and their bathwater

ByEdward W. Carney, Amy L. Ellis, Rochelle W. Tyl, Paul M. D. Foster, Anthony R. Scialli, Kary Thompson, James H. Kim

chapter 25|18 pages

Perspectives on the developmental and reproductive toxicity guidelines

ByAlan M. Hoberman, Elise M. Lewis

chapter |13 pages

APPENDIX 1. S5A (and Amendments) Guidance

chapter 28|22 pages

Perspectives in risk assessment—Drug and vaccine safety

ByJ. Edward Fisher, Jr., Grace S. Lee, Marion F. Gruber, and Melissa S. Tassinari