Mitral regurgitation (MR) affects millions of patients worldwide. It is a progressive condition that can worsen when left untreated, possibly leading to compensatory remodeling of the left ventricle. This can result in reduced functional capacity, poor quality of life, repeat hospitalizations, and even death from heart failure. Open, arrested heart

chapter 1|6 pages

Anatomy of the mitral valvular complex

ByNicolas M. Van Mieghem, Jackie S. McGhie, Margot M. Bartelings

chapter 2|8 pages

The pathophysiology of mitral regurgitation

ByBlase A. Carabello

chapter 3|5 pages

Genesis of the surgical edge-to-edge repair

ByOttavio Alfieri, Michele De Bonis

chapter 4|6 pages

Outcomes from surgical edge-to-edge repair

ByFrancesco Maisano

chapter 5|5 pages

An overview of the literature on surgical mitral valve repair

BySophie Jones, Michael Argenziano, Allan Schwartz

chapter 6|5 pages

Development of percutaneous edge-to-edge repair: The MitraClip® story

ByFrederick St Goar

chapter 7|9 pages

MitraClip® system design and history of development

ByTroy Thornton, Liz McDermott

chapter 8|9 pages

The EVEREST trial results

ByAlice Perlowski, Ted Feldman

chapter 9|11 pages

Outcomes for functional mitral regurgitation

ByJames Hermiller, Douglas Segar, David Heimansohn, Nauman Siddiqi

chapter 10|8 pages

The role of percutaneous mitral repair for high risk patients

ByWillis Wu, Patrick Whitlow

chapter 11|7 pages

Echocardiographic evaluation for mitral regurgitation grading and patient selection

ByEhrin J. Armstrong, Elyse Foster

chapter 12|8 pages

Understanding the limits of patient selection for edge-to-edge repair

ByEhrin J. Armstrong, Jason H. Rogers

chapter 13|14 pages

The basic technique for the Evalve MitraClip® procedure

ByGretchen Gary, Ted Feldman

chapter 14|8 pages

Procedural tips and tricks

BySaibal Kar, Wen-Loong Yeow

chapter 15|5 pages

Training and simulation

ByScott Lim

chapter 16|6 pages

Special techniques for functional mitral regurgitation

ByOlaf Franzen, Stephan von Bardeleben, and Susanna Price

chapter 17|5 pages

The European experience since CE approval

ByCorrado Tamborino, Gian Paolo Ussia, Valeria Cammalleri

chapter 18|7 pages

An interventionalist’s approach to the practical use of TEE guidance

ByHoward C. Herrmann

chapter 19|11 pages

Echocardiographic guidance of MitraClip® mitral valve repair

ByFrank E. Silvestry

chapter 20|5 pages

A critical appraisal of edge-to-edge repair with the MitraClip®

ByPeter C. Block

chapter 21|4 pages

Technique for surgical removal of the MitraClip®

ByLori Soni, Michael Argenziano

chapter 22|7 pages

Special considerations for mitral valve repair after clip therapy

BySubhasis Chatterjee, David A. Heimansohn, John C. Alexander

chapter 23|13 pages

Gross and histologic findings after MitraClip® placement

ByElena Ladich, Masataka Nakano, Renu Virmani