ABSTRACT

Schizophrenia is a unique project reflecting the contribution that Robin M. Murray has made to the field of psychiatry over the past 35 years, with a particular focus on the advances that have been made to the understanding and treatment of schizophrenia.

International contributors have been brought together to pay tribute to Robin Murray’s work and explore the latest findings in the area. Sections cover:

  • neurodevelopment
  • neuroscience and pharmacology
  • neuroimaging
  • genetics
  • cognition
  • social psychiatry
  • treatment.

This book will be essential reading for psychiatrists, clinical psychologists, social and basic scientists whose work is related to major mental illness, as well as admirers of the work of Robin Murray.

part |1 pages

PART I Development

chapter 1|16 pages

The neurodevelopmental hypothesis of schizophrenia

ByKATHERINE H. KARLSGODT, LAUREN M. ELLMAN

chapter 3|11 pages

The black hole of the adolescent brain

ByMATT ALLIN, CHIARA NOSARTI

part |1 pages

PART II Neuroscience

chapter 5|15 pages

The search for madness: A metaphasical trip through the basal ganglia

ByPAUL D. MORRISON

chapter 6|16 pages

Neurophysiological endophenotypes for psychosis

ByMADIHA SHAIKH, ELVIRA BRAMON

chapter 8|14 pages

Animal models of schizophrenia revisited

ByTREVOR W. ROBBINS

part |1 pages

PART III Neuroimaging

chapter 9|7 pages

Application of neuroimaging to the study of psychosis

ByPHILIP MCGUIRE

chapter 10|8 pages

Brain networks and schizophrenia

ByED BULLMORE

chapter 12|22 pages

Gray matter alterations in schizophrenia: Are they reversible?

ByMATCHERI S. KESHAVAN, TEJAS BHOJRAJ

part |1 pages

PART IV Genetics

part |1 pages

PART V Cognition

chapter 18|10 pages

Giftedness and psychosis

ByJAMES H. MACCABE

part |1 pages

PART VI Social psychiatry

chapter 19|14 pages

Towards a social aetiology of psychosis: The case of child sexual abuse

ByPAUL BEBBINGTON

chapter 20|8 pages

Does urban density matter?

ByJANE BOYDELL, JUDITH ALLARDYCE

chapter 21|8 pages

Does higher potency cannabis mean higher risk for psychosis?

ByMARTA DI FORTI, ALESSANDRA PAPARELLI

chapter 22|14 pages

The social determinants of psychosis in migrant and minority ethnic populations

ByCRAIG MORGAN, GERARD HUTCHINSON, PAOLA DAZZAN, KEVIN

chapter 23|10 pages

Stress and psychosis: Professor Murray’s contribution (so far) to the vulnerability–stress model

ByVALERIA MONDELLI, CARMINE M. PARIANTE

chapter 24|11 pages

Chasing gene–environment interactions across the psychiatric universe

ByJIM VAN OS, BART P. F. RUTTEN, RUUD VAN WINKEL AND

part |1 pages

PART VII Treatment

chapter 25|15 pages

How antipsychotics work: Examining trans-synaptic realities

BySRIDHAR NATESAN, SHITIJ KAPUR

chapter 26|13 pages

Metabolic disturbance and schizophrenia

ByEMMA NICHOLSON AND DAVID J . CASTLE

chapter 27|8 pages

Clinical trials and schizophrenia

BySHÔN LEWIS

chapter 28|8 pages

What new evidence tells us about dopamine’s role in schizophrenia

ByOLIVER D. HOWES

part |1 pages

PART VIII Afterword

chapter 29|5 pages

Robin M. Murray: A biographical note

ByANTHONY S. DAVID