The second edition of Nanotechnology in Biology and Medicine is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in life sciences. This technology, which is on the scale of molecules, has enabled the development of devices smaller and more efficient than anything currently available. To understand complex biological nanosystems at the cellular level, we urgently need to develop a next-generation nanotechnology tool kit. It is believed that the new advances in genetic engineering, genomics, proteomics, medicine, and biotechnology will depend on our mastering of nanotechnology in the coming decades. The integration of nanotechnology, material sciences, molecular biology, and medicine opens the possibility of detecting and manipulating atoms and molecules using nanodevices, which have the potential for a wide variety of biological research topics and medical uses at the cellular level. This book presents the most recent scientific and technological advances of nanotechnology for use in biology and medicine. Each chapter provides introductory material with an overview of the topic of interest; a description of methods, protocols, instrumentation, and applications; and a collection of published data with an extensive list of references for further details. The goal of this book is to provide a comprehensive overview of the most recent advances in instrumentation, methods, and applications in areas of nanobiotechnology, integrating interdisciplinary research and development of interest to scientists, engineers, manufacturers, teachers, and students.

chapter 1|16 pages

Nanotechnology at the Frontier of Biology and Medicine

ByTuan Vo-Dinh

section I|318 pages

Nanomaterials, Nanostructures, and Nanotools

chapter 2|28 pages

Self-Assembled Organic Nanotubes: Novel Bionanomaterials for Orthopedics and Tissue Engineering

ByRachel L. Beingessner, Baljit Singh, Thomas J. Webster, Hicham Fenniri

chapter 3|14 pages

Gold Nanoparticles with Organic Linkers for Applications in Biomedicine

ByOlga Shimoni, Stella M. Valenzuela

chapter 4|18 pages

Nucleoprotein-Based Nanodevices in Drug Design and Delivery

ByElizabeth Singer, Katarzyna Lamparska-Kupsik, Jarrod Clark, Kristofer Munson, Leo Kretzner, Steven S. Smith

chapter 5|18 pages

Bimetallic Nanoparticles: Synthesis and Characterization

ByTarasankar Pal, Anjali Pal, Sudipa Panigrahi

chapter 6|30 pages

Nanotube-Based Membrane Systems

ByLane A. Baker, Charles R. Martin

chapter 7|16 pages

Nanoimaging of Biomolecules Using Near-Field Scanning Optical Microscopy

ByMusundi B. Wabuyele, Tuan Vo-Dinh

chapter 8|34 pages

Development and Modeling of a Novel Self-Assembly Process for Polymer and Polymeric Composite Nanoparticles

ByB. G. Sumpter, J.-M. Y. Carrillo, S.-K. Ahn, M. D. Barnes, W. A. Shelton, R. J. Harrison, D. W. Noid

chapter 9|26 pages

Cellular Interfacing with Arrays of Vertically Aligned Carbon Nanofibers and Nanofiber-Templated Materials

ByTimothy E. McKnight, Anatoli V. Melechko, Guy D. Griffin, Michael A. Guillorn, Vladimir I. Merkulov, Mitchel J. Doktycz, M. Nance Ericson, Michael L. Simpson

chapter 11|12 pages

Optical Nanobiosensors and Nanoprobes

ByTuan Vo-Dinh

chapter 12|18 pages

Surface-Enhanced Fluorescence-Based Biosensors

BySamuel Grésillon, Emmanuel Fort

chapter 13|30 pages

Biomolecule Sensing Using Surface Plasmon Resonance

ByH.P. Ho, F.C. Loo, S.K. Kong, S.Y. Wu

chapter 14|18 pages

Molecular SERS Nanoprobes for Medical Diagnostics

ByHsin-Neng Wang, Bridget M. Crawford, Tuan Vo-Dinh

chapter 15|28 pages

Silicon Nanoparticles for Biophotonics

ByMark T. Swihart

section II|368 pages

Applications in Biology and Medicine

chapter 16|34 pages

Nanoscale Optical Sensors Based on Surface Plasmon Resonance

ByAmanda J. Haes, Douglas A. Stuart, Richard P. Van Duyne

chapter 17|18 pages

Synthetic Biology: From Gene Circuits to Novel Biological Tools

ByNina G. Argibay, Eric M. Vazquez, Cortney E. Wilson, Travis J.A. Craddock, Robert P. Smith

chapter 18|18 pages

Recent Trends in Nanomaterials Integration into Simple Biosensing Platforms

ByAndrzej Chałupniak, Arben Merkoçi

chapter 19|16 pages

Nanobiosensors: Carbon Nanotubes in Bioelectrochemistry

ByAnthony Guiseppi-Elie, Nikhil K. Shukla, Sean Brahim

chapter 20|16 pages

Monitoring Apoptosis and Anticancer Drug Activity in Single Cells Using Nanosensors

ByPaul M. Kasili, Tuan Vo-Dinh

chapter 21|11 pages

Biosensing and Theranostics Applications of Gold Nanostars

ByYang Liu, Hsiangkuo Yuan, Tuan Vo-Dinh

chapter 23|62 pages

Integrated Cantilever-Based Biosensors for the Detection of Chemical and Biological Entities

ByElise A. Corbin, Ashkan YekrangSafakar, Olaoluwa Adeniba, Amit Gupta, Kidong Park, Rashid Bashir

chapter 24|30 pages

Design and Biological Applications of Nanostructured Poly(Ethylene Glycol) Films

BySadhana Sharma, Ketul C. Popat, Tejal A. Desai

chapter 25|18 pages

Development of Gold Nanostars for Two-Photon Photoluminescence Imaging and Photothermal Therapy

ByHsiangkuo Yuan, Yang Liu, Tuan Vo-Dinh

chapter 26|30 pages

Surface Plasmon–Enhanced Nanohole Arrays for Biosensing

ByJean-Francois Masson, Maxime Couture, Hugo-Pierre Poirier-Richard

chapter 27|18 pages

Sensitive DNA Detection and SNP Identification Using Ultrabright SERS Nanorattles and Magnetic Beads for In Vitro Diagnostics

ByHoan T. Ngo, Naveen Gandra, Andrew M. Fales, Steve M. Taylor, Tuan Vo-Dinh

chapter 28|24 pages

Gold Nanorods for Diagnostics and Photothermal Therapy of Cancer

ByXiaohua Huang, Mostafa A. El-Sayed

chapter 29|18 pages

Applications of Nanotechnology in Reproductive Medicine

ByCeline Jones, Natalia Barkalina, Sarah Francis, Lien Davidson, Kevin Coward

chapter 30|10 pages

Theranostic Nanoprobes for SERS Imaging and Photodynamic Therapy

ByAndrew M. Fales, Tuan Vo-Dinh

chapter 31|16 pages

Virus-Like Particle-Mediated Intracellular Delivery for Nanomedicine

ByJadwiga Chroboczek, Inga Szurgot

chapter 32|8 pages

In Vivo Sensing Using SERS Nanosensors

ByJanna K. Register, Andrew M. Fales, Hsin-Neng Wang, Gregory M. Palmer, Bruce Klitzman, Tuan Vo-Dinh