Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects.

Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation.

Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.

chapter 1|31 pages

Brain circuitry in ageing and neurodegenerative disease

BySharna Jamadar

chapter 2|33 pages

Alzheimer’s disease

Prodromal stages and dementia
ByKerryn Pike, Glynda Kinsella

chapter 3|23 pages

Parkinson’s disease

ByRobert Iansek, Mary Danoudis

chapter 4|28 pages

Huntington’s disease

ByAileen K. Ho

chapter 5|27 pages

Experience-dependent modulation of neurodegenerative disorders

Huntington’s disease as an exemplar
ByIsaline Mees, Harvey Tran, Thibault Renoir, Anthony J. Hannan

chapter 6|20 pages

Fragile X-associated tremor ataxia syndrome

ByRachael C. Cvejic, Julian N. Trollor, Darren R. Hocking

chapter 7|23 pages

Multiple sclerosis

ByJoanne Fielding, Meaghan Clough

chapter 8|13 pages

Dementia with Lewy bodies

ByOlivia Salthouse, Jenny Bradshaw, Michael Saling

chapter 9|30 pages

Motor neuron disease

ByWilliam Huynh, Thanuja Dharmadasa, Smriti Agarwal, Jashelle Caga, Matthew C. Kiernan

chapter 10|16 pages

New clinical neuroscience technologies for treating neurodegenerative disorders

ByWei-Peng Teo, Alicia M. Goodwill, Peter G. Enticott

chapter 11|7 pages

Conclusions and last thoughts

ByJohn L. Bradshaw